Cancer Kryptonite: Using Deadly Disease to Cure Deadly Disease
After reviewing the study of the effects of chimeric antigen receptor-modified T cells (CAR T-cells) on acute lymphocytic leukemia, it appears that this type of treatment shows promise for the treatment of this and many other difficult-to-kill cancers. This technique was pioneered and developed by Dr. Carl June. He began his research on T cells in the late 1980s to early 1990s while in the Navy. The research he would do and the other researchers he would meet at this time would pave the way for what could be considered to be groundbreaking cancer research today. What started as the study of T cells and their relationship with the HIV virus specifically, would turn into the
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to recognize a “self” cell from a “non-self” cell,
2. mount a successful response/attack,
3. remember each specific pathogen/antigen for future attacks.
To be able to recognize a “self” cell from a “non-self” cell, T cells have receptors on their surfaces that recognize antigens on the surfaces of other cells. When one of these antigens, or parts of the disease that the immune system recognizes as “non-self”, is recognized by a T cell, an immune response is launched and T cells begin multiplying rapidly to fight off the infection. This rapid multiplication creates two different types of T cells: helper and cytotoxic. The helper T cells help to create more T cells and the cytotoxic T cells are the killers. They attack the cells with the antigen that the body has recognized as “non-self.” Once the “non-self” cells are destroyed, some of these new T cells that have been created to fight off this specific infection will stay around to fight any future infection with the same antigen. This is called “memory” (Dr. T. White, Microbiology lecture, May 2015). Dr. June and his team have based their research on this immune response, but with an interesting twist. The research conducted by Dr. June while in the Navy taught him plenty about the efficiency the HIV virus possesses in DNA delivery and about the response of T cells to disease. He would use this knowledge, and the knowledge of his peers, to perfect for the first time the procedure he would use in
a. This function is mediated by T cells and B cells (memory cells) in our body via adaptive immunity. The adaptive immune system evolved in early vertebrates and allows for a stronger immune response as well as immunological memory, where each pathogen is “remembered” by a signature antigen. The adaptive immune response is antigen-specific and requires the recognition of specific “non-self” antigens during a process called antigen presentation. Antigen specificity allows for the generation of responses that are tailored to specific pathogens or pathogen-infected cells. The ability to mount these tailored responses is maintained in the body by memory cells. Should a pathogen infect the body more than once, these specific memory cells are used to quickly eliminate it. So basically killer T cells will identify antigens present on foreign cells. These antigens are not found in any of the cells inside our body. Therefore, T cells will identify them and kill them.
The National Cancer Moonshot is the Obama Administration’s initiative to facilitate the progress of cancer research. Announced during the 2016 State of the Union, the Moonshot is being headed by Vice President Joe Biden with the goal of doubling the rate of scientific advancement over the next five years. At the moment, the progress is largely organizational and informative as the Vice President hopes to connect large swathes of the scientific community. A final Moonshot report is due at the end of the year, but action is expected to increase dramatically this fall.
Barbara Ehrenreich, Audre Lorde, and Meri Nana-Ama Danquah’s illness narratives do more than recount stories of illness. The narratives depict resistance to normalization or becoming normate by making visible the larger structural inequities. The narratives are showing how the systems that are supposed to aid and heal those who are ill, but are actually reinforcing the inequities.
I agree it was smart to take action against her breast cancer quickly before it took her away just as her mother had. I'm glad she wrote about her fight against it and wants to encourage other women to seek help and make their own decision of what they want to do. After reading "Hopeful Glimmers in Long War on Cancer" there's still hope for people with cancer and by now there might be more information about it so there's more choices to make for
The cyclotron used the same concept that a circular particle accelerator used. The purpose of the accelerator to be shaped in a circular shape is to speed up the particles as they revolve around this path. When they revolve around this path they gain velocity and speed. The formula for velocity is displacement/ time. The amount of change that there is in the position of the particle affects the velocity of the particle. The formula of speed is distance over time. The speed transforms as the same time that the particles transform energies through the magnetic fields that they are interacting
Cancer immunotheraphy is a concept that has been around for centuries. Back in the 1800s, a bone surgeon named William Coley injected his patients with a vaccine consisting of killed bacteria hoping it would stimulate the body's defense system. During the 1990s, physicians treated people with cancer with a cytokine treatment. This treatment involved high amounts of interleuken-2 (IL-2) and interferon-γ (IFNγ), also known as inflammatory cytokines. These inflammatory cytokines were released by white blood cells that fight infection (T cells). However, this treatment can have very dangerous side effects such as vascular leakage and kidney damage, but some people that received the cytokine treatment have lived for decades. In the year of 1996,
For years people have been looking for a cure for the devastating disease of cancer. Cancer is the third highest killer in the US with over 2,500,000 victims per year. Oncologists and scientists around the country are researching all forms of cancer in an effort to understand, treat, and ultimately defeat this disease. Already there have been numerous advances in the field, such as chemotherapy and gene therapy. One advance has been the use of a cell process known as apoptosis. By harnessing this normal cell process, scientists hope to have found an effective way to combat cancer.
Immunotherapy for cancer treatment has had tremendous growth recently with increased awareness and knowledge of the immune system and potential means to manipulate it for therapeutic intent. Progress in the treatment of viral infections including CMV, EBV, HHV-6, utilization of immune checkpoint blockade for melanoma, non-small cell lung cancer, and Hodgkin Lymphoma, as well as rapid emergence of genetically modified T cells against CD19+ B cells have contributed to the growth in this area.Antibody-targeted therapy has now become standard of care for many malignancies, and the multi-domain utilization of antigen-specific adoptive T-cell therapy has shown great promises. 4 While our understanding of B cell and T cell and our ability to
Cancer is a disease, caused by uncontrolled cell division to form a malignant growth or tumour in the body.
Many humans in the world suffer from cancer. This disease has caused many people to lose their life or even their loved one’s life. Researchers have done many studies to try and tackle this deadly infection, but everything they have tried has either caused cancer to progress or come
Genetic engineering allows biologists to manipulate an organism's genomes by utilizing biotechnology (Moulton, 2004 ). The Talimogene Laherparepvec virus, otherwise known as T-vec, is an oncolytic virus. A oncolytic virus, is a virus that destroys cancerous cells. The T-vec virus has recently had successful results for treating melanoma cancer. The virus originated from the herpes simplex virus 1 and has been genetically altered to help destroy cancer cells.The virus gets injected into the lesions, lesions are areas on or in the body that have been damaged . Not only does the virus destroy cancer cells, it also activities the immune system to attack the cancer cells. Many changes were done to diminish the virus, expand the selective for the cancer cells, and release the cytokine. The modifications that were implanted in the virus were, HSV-1 strain (JS1) which is the DNA set of the herpes virus, that increases the death of the tumour cells. To delete ICP34.5, that stops the HSV infection in the cells that are not tumorous, and will provide selective tumour duplication. As Well as the deletion of ICP47 that allows antigen presentation, an antigen is a substance that helps enable an immune response. Placing in the US11 will
You never think it will happen to you. “27 year old man killed in freak lightning strike.” “24 year old surfer killed by rare shark attack.” “40 year old man killed by RARE skin cancer.” But then it does. You don’t expect it and you are definitely not ready for it. The next many years are difficult, full of tears and grief, and full of questions… After eleven, it has improved. However, I still ask, “Why?” “Why did it have to be a RARE cancer?” “Who has even heard of nasal cancer?” “Why did he die to a disease he spent his life seeking to cure?” In May of 2004, scientist Han Mo Koo passed away from NK-T cell lymphoma and my life changed forever.
When a particular pathogen reinfected the body, it is met by an expansion of clonally selected cells, which has an antigen-specific memory toward the pathogen. This allows it to undergo much more rapid differentiation into effector cells when compared to the first antigen encounter. This result in a stronger and faster secondary immune response that eliminates the pathogen before it affects the body.
Cancer is figured to be the second leading causes of morbidity and mortality worldwide. With approximately 14 million new cases and 8.2 million cancer related deaths in 2012, alone .Why are so many people stuck suffering with this deadly disease? Millions of dollars have been invested into cancer research, yet there is no cure. Are these pharmaceutical companies focus on finding a cure for cancer or concentrating on elongated treatments in order to lengthen their pockets? We must first understand that cancer is big business earning huge profits. Nonetheless, the cancer industry is spending virtually zilch of its multi-billion dollar resources on effective prevention strategies, like dietary guidelines, exercise, natural remedies and herbs proven to cure cancer. Instead, it pours its money into treating cancer, not preventing or allaying it.
Scientist are performing an experiment to cure cancer. First you will be immortal because when people have cancer they die after losing cancer. They asked you if you could volunteer for this experiment to help cure cancer for the common good. Would you sign up for his experiment? I say yes to this experiment because I like helping people and saving people's lives because that makes me feel good. The experiment is immortality to cure cancer. The scientist theory of curing cancer is they can't cure cancer because no one has lived long enough during the stages of cancer to find out how to solve cancer. Their is a supply of unlimited amount of these immortality pills. Once 3 generations have gone by everyone you know has died and people are uncomfortable