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Candidemia Research Paper

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Candida is a yeast responsible for the majority of the systemic fungal infections in humans. The occurrence of nosocomial bloodstream infections (candidemia), has risen considerably in latest years, [1] being the fourth pathogen isolated in blood cultures in the North America[2]. In Europe, it ranks among the fifth to tenth most frequently isolated microorganism [3] and in a global assessment of intensive care units (ICUs), the incidence of candidemia was found to be 6.9 per 1000 patients. Whereas general incidence of candidemia has raised, possibly due to a growing number of patients with compelling diseases and risk factors for candidemia, health care units such as ICU or stem cell transplant units have noticed a decrease in candidemia after using fluconazole prophylaxis [4]. The list of risk factors is long, where immunocompromised patients, such as those suffered from solid tumors or hematological malignancies are at the highest threat for developing candidemia, also other well known risk factors include ICU stay, prolonged antibiotic use or multiple invasive procedures. More lately, patients groups characterized by several comorbidities, such as elderly, require for parental nutrition, are increasingly being documented as being at risk of candidemia. …show more content…

This change in the epidemiology of candidemia represents an important challenge for empirical management strategies because some species of non-albicans such as Candida glabrata and Candida krusei exhibit a resistance or variable susceptibility to azole antifungal. IDSA guidelines suggest that Fluconazole for stable patients and echinocandins in the presence of haemodynamic instability, previous use of fluconazole or for patients who are at high risk of infection due to C.glabrata or C. krusei

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