Canine Osteosarcoma Research Paper

An earlier study also confirmed that though quite rare, canines also suffered from neurological diseases parallel to human Alzheimer’s and provided and accurate portrayal of their human counterparts in terms of cellular degeneration and areas affected by the disease. (Barsoum, Callahan, Robinson & Chang 2000). This study also notes that the common body sizes and physiology between canines and humans is significant enough to use canines in an attempt to stand in for a human subject. They also list some of the diseases that present in Canines and mimick human forms such as Genetic Neuronal Ceroid Lipofuscinosis (compared to human seizures), Hereditary Canine Spinal Muscular Atrophy (similar to Human muscle atrophy), Mucopolysaccharidosis and MPS 1 (similar to the human presentation of the same disease).

This cancer is a bone cancer that attack the bones, especially large bones. This cancer is named osteogenic sarcoma(Osteosarcoma) for medical term (“Osteosarcoma”, n.d.). Osteosarcoma mostly affects people under 25 years old, and it can affect old people but it is really rare(“Osteosarcoma: An Introduction.”, 2012). When this cancer attacks, it grows bones, and any type of bone (“Bone cancer”,2013). This cancer is an ancient disease that we started to recognize in 1805. Most of the symptoms are on the bones (“Bone cancer”,2013). It also is not contagious so its not passed from person to person like other diseases.

Sadly, one in three people, one in four dogs, will face some form of cancer in their lifetime. The hope is that will change one day through the work of many wonderful organizations and initiatives including One Cure. One Cure initiated at CSU, was founded on the principle that cancer is one disease. Cancer is cancer. Because it’s the same disease what is learned in pets being treated for cancer holds promise to also benefit people, and vice versa. This approach is known as comparative oncology and is the core of the One Cure concept. Furthermore, treatment breakthroughs come through collaboration between scientists and doctors who are working with both people and pets. The mission of the CSU Flint Animal Cancer Center is to improve the prevention, diagnosis, and treatment of cancer in pet animals, translating their research and knowledge to also benefit people with

Osteosarcoma is an ancient disease that still has some mystery behind it. Osteosarcoma is a type of cancer that starts in the bones. It is also the most common type of bone cancer, and makes up 65% of all bone cancer. However, it is a very rare cancer and has fewer than 20,000 cases per year in The USA. The cells that form an osteosarcoma make bone matrix, similar to osteoblasts. However, the bone matrix of an osteosarcoma is not as strong as a bone matrix from an osteoblast, and therefore is not as strong as normal bones. The most common age group affected by osteosarcoma is children and young adults. However, osteosarcoma can occur at any age. Osteosarcoma is most commonly found in areas of the bone that grow quickly, which is why children are more likely to get this type of cancer. The most common place to find osteosarcoma is the end of long bones, especially in the knee, distal femur, and proximal tibia. The proximal humerus is typically the most common site. The treatments of

The School of Veterinary Medicine of the University of California, Davis studied the effects of neutering on Golden and Labrador retrievers. They found that male Golden Retrievers with joint disorders is five percent in intact dogs and up to twenty-seven percent occurred in neutered dogs. Male Golden Retrievers with cancer is eleven percent in intact dogs and up to seventeen percent in neutered dogs. Female Golden Retrievers with joint disorders is five percent intact and twenty percent neutered. Female Golden Retrievers with cancer is three percent intact and fourteen percent neutered. Male Labrador Retrievers with joint disorders is five percent intact and twelve and one-half percent neutered. Male Labrador Retrievers with cancer is four

For example, dogs need daily walks, this will help you get fit and stay more healthier. This question, asked in an interview: “How often do you walk your dog?”, was answered by Francisco Valderas in room 21 Ms. Folendorf’s class. Franciso answered: “You would walk your dog on a daily basis, for health.” Also, some dogs detect cancer. For example your dog would scratch or sniff an area, that actually turns out to be cancerous. According to Unexpected Side Benefits of Having a Dog from DogVacay.com, states this “ Dogs can be anything, including some dogs that detect cancer.” I know what your thinking mom and dad: “Dogs can’t do that!” Here’s some evidence. Get on this document and go to the very bottom of the page and click on the link to the “Dog Cancer Video”. So there you go, that is why dogs are good for your

One in five dogs in the United States is afflicted with osteoarthritis, making it one of the most common chronic diseases for dogs. This condition damages the dog's cartilage or other joints.

You can keep them healthy by not having them become overweight, reduce exposure to toxins, and Feed an anti-inflammatory diet. The website healthypets.mercola.com state “Allow your dog to remain intact (not neutered or spayed), at least until the age of 18 months to two years. Studies have linked spaying and neutering to increasing cancer rates in dogs. A 2002 study established an increased risk of osteosarcoma in both male and female Rottweilers neutered or spayed before the age of one year. Another study showed the risk of bone cancer in neutered or spayed large purebred dogs was twice that of intact dogs.” This is important because the information shows that following these guidelines can keep your pet safe and healthy from malignant

Six million dogs will die of cancer this year alone. That’s a lot of dogs, and the number is rapidly growing each year. Canine cancer comes at birth for some dogs, but may be preventable for others. Cancer is the number one cause of dog deaths in the world, yet has some of the harshest and least effective treatments. Canine cancer is widespread and more should be done to prevent such a deadly disease.

Lymphoma is a type of cancer that originates in the lymph nodes. The most common type of lymphoma in golden retrievers is Multicentric Lymphoma. Multicentric Lymphoma is a type of lymphoma that involves all the peripheral lymph nodes. You can identify these lymph nodes by X-rays, ultrasounds, biopsies, etc. Before treatment for this cancer can begin, you must first make sure the health and well-being of the patient and client are okay; letting the client know what measures will be taken to attack the cancer. Once the client has willingly agreed to the treatment, knowing all possible complications and symptoms, you may proceed with the physical examination.

The dog is now restless and in agonizing pain and very irritable. The owners keep saying that he sounds like he's choking they wonder if he just ate the bone wrong. The white blood cells haven’t come back for me to see what I've been doing. The owners still can’t tell why the dog is choking and irritable running into doors not knowing why. They took him to an “emergency vet” but they didn’t test for me. They just said he had gotten into something and it “would be gone in a few days” Little did they know this dog would be ferocious and attacking innocent dogs.

Appearance of Metastatic Bone Disease,’’ reported by Ng et al in the June 20 issue of

Ostearthritis and operative procedures are the most common causes of pain among dogs. Statistics show that one out of five adult dogs suffer from this debilitating condition. Dog arthritis is brought by the deterioration of joints and cartilage resulting to limping gait, difficulty in engaging in activities, and decreased movements of the affected joint.

Matrix metalloproteinase-3 (MMP-3, is one of several matrix metalloproteinases (MMPs) family that has been observed in several malignant tumors, including breast, colon, cervical and lung cancers, where its expression correlates with the invasion and metastasis of these tumors. However, the roles of MMP-3 in osteosarcoma are totally unknown. In this study, we examined the expression of MMP-3 in 15 primary and metastatic osteosarcomas with case-matched adjacent normal tissues by immunohistochemistry and quantitative RT-PCR. MMP-3 expression were expressed in 86.6 % (13/15) of the osteosarcoma tissues and the expression levels of MMP-3 were significantly higher in metastatic tumors than in primary osteosarcoma tumor tissues. Further, we investigated the expression of MMP-3 in osteoblast and osteosarcoma cells and found that MMP-3 was highly expressed in osteosarcoma cells compared to osteoblast cells. Knockdown of MMP-3 by siRNA in osteosarcoma cells significantly inhibited their migration and invasion properties. These findings suggest that MMP-3 expression is deregulated in osteosarcoma tumors, potentially contributing to metastasis and might be a promising marker for the prognosis and therapy of metastatic osteosarcoma.

Osteosarcoma is a frequent primary malignant cancerous tumor of the skeleton characterized by the direct formation of immature bone or how it arises in the osteoid tissue in the bone (Picci). This type of bone cancer develops in the osteoblasts cells in normal bone. It begins in the bones but it can sometimes spread to other areas of the body including organs, such as lungs, and bones. Osteosarcoma unfolds in areas where the bone is growing fast because of the uncontrolled growth of the cells in the bone. “In fact Scientist have not discovered the causes of most cases of osteosarcoma” (Ryan). This is a