Canine's Thyroid Disease

Hashimoto’s Thyroiditis, also called Hashimoto’s disease is an autoimmune disease in which the body’s immune system attacks the thyroid gland. It was named for the Japanese surgeon who discovered it in 1912 The thyroid is a small butterfly shaped gland in the front of the neck. The thyroid makes hormones called T3 and T4. These hormones regulate metabolism. The thyroid is controlled by hormones of the pituitary gland, which is also called the “master gland.” It is a pea-sized gland located in the base of the brain which, among others, makes thyroid stimulating hormone, or TSH. TSH stimulates the thyroid to make thyroid hormone. With Hashimoto’s disease, the thyroid cells are damaged resulting in the inability to make enough thyroid

The iodine uptake with hyperthyroidism is greater than normal. This means that the body produces too much thyroid, meaning there is too much

3. The subject who was diagnosed with hyperthyroidism was given propylthiouracil (prevents Thyroxine production and conversion

Week 3 – LOM Assignment The thyroid is responsible for taking iodine and converting it into thyroid hormones which are released into the blood stream and transported throughout the body where they control metabolism.1 The thyroid is a vital part of the human body as every cell in the body depends on it for metabolic regulation. Too much or too little thyroid hormone secretion can result in hyperthyroidism or hypothyroidism. Hyperthyroidism is caused when the thyroid secretes too many thyroid hormones. Hyperthyroidism causes a rapid heart rate, elevated blood pressure and tremors. Other symptoms include increased nervousness, inability to concentrate, weakness, restlessness, difficulty sleeping, frequent bowel movements, weight loss and irregular

The health care provider ordered blood work that included thyroid-stimulating hormone, triiodothyronine, thyroxine, and radioactive iodine uptake to confirm the diagnosis of hyperthyroidism. The labs returned with an elevated level of triiodothyronine and thyroxine, while the thyroid-stimulating hormone was decreased. There was also an

Commonly, problems with the thyroid involve an abnormal production level of these hormones. It is called hyperthyroidism if there the thyroid hormones are overproduced, and this can cause things like Graves’ disease, Toxic adenomas, and subacute thyroiditis (7). Hypothyroidism is the underproduction of the hormones which can be caused by an inflamed thyroid, iodine deficiency, a non-functioning thyroid gland and more. Hypothyroidism is especially dangerous in infants and newborns as the lack of these thyroid hormones can lead to mental retardation and dwarfism (7). However, in humans hypothyroidism can be caused by things such as a pituitary disorder, a defective thyroid or a lack of the gland completely. (7)

Thyrotoxicosis is a clinical condition caused by excess circulating serum thyroxine (T4), triiodothyronine (T3), or both with suppression of thyroid-stimulating hormone (TSH). A negative feedback loop involving the hypothalamus, pituitary, and thyroid gland regulates the production and release of thyroid hormones. (Fig. 1) The hypothalamus releases thyroid-releasing hormone (TRH), stimulating the pituitary gland to release TSH, in turn stimulating the thyroid gland to release T4 and T3. Enhanced production of T4 and T3

Like many other organs and cells in the body, the heart is affected by decrease secretion of thyroid hormone. The heart mainly relies of T3, for it is the hormone that is transported into the myocytes. T3 binds to thyroid hormone receptors, which is the start of its many cellular actions. The activation of T3 in the myocytes is responsible for systemic vascular resistance, heart rate, contractility, and blood volume. In primary overt hypothyroidism, there is a hyposecretion of T4 and T3, which affects the cardiovascular hemodynamics. If there is not a sufficient amount of T4 to convert to T3, then there is not enough T3 available for the myocytes to carry out their cellular reaction. As a result, there is a decrease in cardiac output and cardiac contractility with an increase in peripheral vascular resistance. People with cardiovascular dysfunction due to primary overt hypothyroidism typically present with bradycardia, hypertension, dyspnea on exertion, and edema. However, most of the cardiovascular dysfunction responds well with thyroxine replacement therapy (Danzi;

A radioactive scan may be done to see whether the entire thyroid gland is overactive. In this scan, radioactive iodine is administered to the patient which then may demonstrate diffuse enlargement and increased uptake of radioiodine. The extent of this uptake helps determine the dose of radioactive iodine necessary for treatment. Ultrasound may also be utilized to help determine the size and location of the affected thyroid gland, which can then be paired with the radioactive

The thyroid gland is found in the front of the neck and produces two main hormones. The hormones are called thuroxine (T4) and Triiodothyronine (T3). Together these hormones regulate the body’s metabolism by increasing energy use in cells, regulate growth and development, help to maintain body temperature and aid in oxygen consumption. These two hormones are regulated by hormones produced by the hypothalamus and pituitary gland. The hypothalamus senses changes in body’s metabolic rate and releases a hormone known as thyropin-releasing hormone (TRH). This hormone then flows through connecting vessels to the pituitary gland which signals it to release another hormone. This hormone is known as thyroid-stimulating hormone (TSH). TSH then makes

An 18-year-old woman presented with persistent bilateral lactation, excess body weight with leg swelling and unbalanced gait, and recurrent hypercalcemia. Patient experienced increasingly frequent headaches and visual field changes. Developed panhypopituitarism and central diabetes insipidus (DI) after going through with transsphenoidal resection of a pituitary macroadenoma. Patient was treated with levothyroxine (T4) for secondary hypothyroidism. She received other hormone replacement therapy, including desmopressin acetate, conjugated estrogen, growth hormone, and bromocriptine. She developed recurrent kidney stones and diagnosed with primary hyperparathyroidism. She was also found to have multiple thyroid nodules and underwent a 4-gland

The main goal of the treatment is to control the over-production o thyroid hormones. The anti-thyroid medications, for instance, have methimazole and propylthiouracil (PTU), which blocks the production of hormones of the thyroid gland. However, there could be some side effects such as allergies and hyperthyroidism may return if the drug is not being used. Sometimes, radioactive iodine treatment is preferred by doctor because it provides a long-term solution, unlike the medications. According to Toft, “Radioactive iodine works by destroying thyroid tissue cells, thereby reducing your thyroid hormone levels.” RAI is usually given as a capsule or in a water-based solution, and the treatment may take months to be effective. The last type of treatment is the thyroidectomy, which is a surgery. The removal of the thyroid gland may be required for some patients that cannot take or tolerate the medications or when those medications have no effect in controlling the overproduction of T3 and T4. Although the total removal of the thyroid gland treats most of the patients, the surgery always results in hypothyroidism, which is a condition where the body lacks sufficient thyroid hormones. In this case, patients that undergo total thyroidectomy need to intake a daily

(2010) include all the general information about thyroid cancer in their research, such as the treatments and types of thyroid cancer. Small lumps may be found on the thyroid which store extra thyroid hormones, they are usually benign. It is possible for those smaller nodes to develop into cancerous tumors, causing thyroid cancer. Papillary carcinoma is the most dominant form of thyroid cancer with 80% of all thyroid cancer cases being of that type. Cancer that can move to the bones and lungs of the patient is considered follicular carcinoma thyroid cancer. Other forms of thyroid cancer do exist but in a very small percentage. Treatment for thyroid cancer varies between chemotherapy, surgery and radiation. Surgery is commonly used to extract a part or all of the thyroid gland. To confirm that all of the cancer has been extracted, radioactive iodine is given. Radioactive iodine can eliminate all remaining cancer cells after surgery. Chemotherapy is a last resort when other methods

, approximately 500 cases have been reported ; in only 5-15% of cases, hyperthyroidism with low RAI uptake in the thyroid bed were found (3,10) . (1,11,13

Laboratory Report/ Theres Castle/ Homeostatic Imbalances of Thyroid Function/ Virgil Stoia/ 10.20.2014/ Page [2] of [3]