Cardiac Troponins And The Cardiac Myocyte

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Cardiac Troponins are specific to the cardiac myocyte and have central role in diagnosing ACS. They are found to be specific and sensitive, in addition they also provide prognostic information which adds to their utility in managing and diagnosing of CAD. Constant change in levels of Cardiac Troponins is required to define ACS. CKD patients with advanced disease have misfortune of having both a dramatically high rate of cardiac mortality paired with decreased ability to detect, it due to elevated Cardiac Troponin levels.[6]. mortality in dialysis patients from cardiovascular disease is substantially higher than the general population as depicted in Figure1.

Figure 1: [7]

Figure 1: Cardiovascular disease mortality by age, race, and gender in the general population and in dialysis patients. Cardiovascular mortality is defined as death due to arrhythmias, cardiomyopathy, cardiac arrest, myocardial infarction, atherosclerotic heart disease, and pulmonary oedema. Data from the general population are from the National Centre for Health Statistics multiple cause of mortality files 1993. Data from dialysis patients include haemodialysis and peritoneal dialysis combined from USRDS 1994-1996. Reprinted with permission from Am J Kidney Dis 32[Suppl 3]: S115, 1998.
Often, persistently elevated levels of troponins are found in patients having CKD, which reduces the specificity of the test considerably. Increasing levels
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