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Cardiomyopathy Case Study

Decent Essays

Cardiac abnormalities are often detected during physical examination of hyperthyroid

cats1

. These abnormalities are diverse and can appear as subtle, clinically inconsequential

myocardial changes but also as severe changes which could be associated with the development

of heart failure leading to death. Often times, it is difficult to determine whether cardiac

abnormalities that persist after the treatment and resolution of hyperthyroidism are the result of

the hyperthyroidism or a primary cardiac disease1

.

The most common form of primary myocardial disease in cats is hypertrophic

cardiomyopathy (HCM), which is the hypertrophy of a nondilated ventricle that occurs when

there is no metabolic stimuli or altered blood flow such as hyperthyroidism …show more content…

Over time, cats may develop an enlargement or thickening of the left ventricle2

. Both lesions of

the heart may result in echocardiographic changes which are indistinguishable from one another,

and therefore echocardiogram is not always a useful tool in differentiating between primary and

secondary cardiomyopathy.

This paper evaluated plasma concentrations of two cardiac biomarkers; N-terminal

probrain natriuretic peptide (NT-proBNP) and cardiac troponin I (cTNI). NT-proBNP is secreted

in response to myocardial stretch, and cTNI is released from the cytosol of damaged

cardiomyocytes2

. These biomarkers were evaluated in the plasma to identify if a possible

correlation between plasma concentrations of the biomarkers and cardiomyopathies existed.

Previous studies in hyperthyroid humans have shown that increased plasma concentrations of

NT-proBNP and T4, which stimulates BPN release from cardiomyocytes, indicating a change in

the heart due to hyperthyroidism3

. No such study has been done to compare plasma

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