Cardiovascular Diseases

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Several researches investigated the benefits of knowing the genomic sequence and how it is associated with the risk of certain disease. There are several arguments contrary to genomic research and some are supporting it. For instance The Director of Cancer genetics center at Johns Hopkins university says “it may become one important determination in patient care, but certainly not the only one” [source]. Several studies doubts that genomic research providing any extra information about the possibility of getting common diseases, including heart disease and stroke, since such a disease also involves one’s daily routine and lifestyle [res]. On the other side several papers showed the impact that the genomic research can have on the medical…show more content…
The new findings help better understand the cardiac development and effect on clinical care for patients with CHD. In general, cardiovascular disease (CVD) is a complex disease; no one single gene mutation is responsible for it. Therefore a new genome-wide association study (GWAS) was launched to investigate a wide range of genes that is associated with the CVD.
Genome-Wide associated Study is a study involving hundreds of thousands of single-nucleotide polymorphisms (SNPs) to be examined in relation to diseases in hundreds of thousands of subjects. GWAS studies compare the DNA of various subjects having different phenotypes of a specific disease, to the control subjects in order to identify the genome associated with the disease. Another way to run GWAS studies is by collecting thousands of hundreds of DNA samples. Using SNPs arrays genetic variants are read, if one variant has a higher frequency in subjects with a specific disease, which reveals that this genetic variant is linked to the disease.
A GWAS study was done by O’Donnell and his team, revealed 20 new genetic loci related to myocardial infraction and other CVD phenotype (O'Donnell & Nabel, 2011; Schnabel, Baccarelli, Lin,
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