Cardiovascular Diseases and Infection/Inflammation

1783 Words Jan 28th, 2018 7 Pages
This association exists in two patterns: an association between chronic low-grade inflammation/infection and the slow process of atherogenesis, and an association between acute systemic inflammation and a transient increase in the risk of an acute cardiovascular event. It has been suggested that changes in endothelial function may underly the association between inflammation and acute cardiovascular event risk.29 Impaired endothelial function appears to be mediated, at least in part, by systemic inflammation in human vascular disease states. The endothelial dysfunction occurs through a variety of mechanisms such as increased vascular oxidative stress, activation of redox-sensitive transcriptional pathways, and decreased eNOS function. Enhanced formation of reactive oxygen species in vascular wall and reduced endothelial function have all been associated with systemic inflammation.30
As mentioned previously, generation of NO by eNOS requires the enzymatic cofactor BH4. In the setting of vascular disease, reduced BH4 bioavailability leads to enzymatic uncoupling of eNOS and formation of O_2^• instead of NO. Investigations have demonstrated a complex association between plasma biopterins, inflammation, and endothelial function. Plasma BH4 is correlated with high-sensitivity C-reactive protein (hsCRP) but inversely associated with endothelial…
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