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Case Study : Demonstration Of An Anti-Oxidative Frress

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Demonstration of an anti-oxidative stress mechanism of quetiapine
Implications for the treatment of Alzheimer’s disease
Authors
* Haiyun Xu, o o
*
o
*

Haitao Wang, o * o *

Lixia Zhuang, o *

Bin Yan, o *

Yingxin Yu, o *

Zelan Wei, o *

Yanbo Zhang, o *

Lillian E. Dyck, o *

Steven J. Richardson, o *

Jue He, o *

Xiaokun Li, o *

Jiming Kong, o *

Xin-Min Li o o o *

* First published: 28 June 2008Full publication history
* DOI: 10.1111/j.1742-4658.2008.06519.x View/save citation
* Cited by (CrossRef): 19 articles
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X.-M. Li, Department of Psychiatry, Faculty of Medicine, University of Manitoba, PZ432-771 Bannatyne Avenue, Winnipeg, Manitoba, Canada
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Furthermore, new compounds formed by quetiapine and OH• were observed in MS analysis. Finally, we applied A?(25-35) to PC12 cells to observe the effect of quetiapine on living cells. A?(25-35) increased levels of intracellular reactive oxygen species and calcium in PC12 cells and caused cell death, but these toxic effects were prevented by quetiapine. These results demonstrate an anti-oxidative stress mechanism of quetiapine, which contributes to its protective effects observed in our previous studies and explains the effectiveness of this drug for Alzheimer’s disease patients with psychiatric and behavioral complications.
Abbreviations
AD
Alzheimer’s disease
APD
antipsychotic drug
APP
amyloid precursor protein
A?
amyloid ?
EPR
electron paramagnetic resonance
HBSS
Hanks’ balanced salt solution
PD
Parkinson’s disease
PS-1
presenilin-1
ROS
reactive oxygen species
ThT
thioflavin T
Quetiapine is an atypical antipsychotic drug (APD) for the treatment of symptoms in patients with schizophrenia. This drug effectively alleviates positive and negative symptoms as well as cognitive impairment [1–3]. In addition, quetiapine is well tolerated and causes the lowest incidence of extra-pyramidal symptoms [1,4]. Moreover, quetiapine ameliorates psychotic symptoms in patients with Alzheimer’s disease (AD) and Parkinson’s disease (PD), and improves cognitive function in patients with these neurodegenerative diseases [5–8]. The therapeutic effects
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