Case Study: Hibiscus Gellan Gum

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1.1. Hibiscus rosa-sinens
The mucilage of this plant has disintegrating properties, it contains L-rhamnose, D-galactose, D-galactouronic acid, and D-glucuronic acid [6,28]. Shah and Patel prepared acelofenac ODT by DC using 6% of this disintegrant, the disintegration time was found to be 20 seconds. The results of Swelling Ratio (SR) , angle of repose, bulk density and compressibility index were observed as 9, 26.5oC, 0.65g/cc and 16% respectively [40] which indicates excellent flow and good compressibility according to European pharmacopeia classification [41].

1.2. Gellan Gum (Kelcogel®)
Gellan gum (figure 5) is a linear anionic water soluble biodegradable polysaccharide obtained from Pseudomonos elodea. It consists of tetrasaccharide repeat structure [5,6]. It showed disintegrating properties compared to that of other commercially available disintegrants. Upon solvatation, swells rapidly -being hydrophilic- and cause tablet disintegration. At 4%, it showed good disintegration profile and less time needed for 90% drug release compared to Ac-di-sol and Kollidone CL [42].
It is extracted from carob tree seeds. It is used as thickening, gelling, disintegrating and binding agent [10, 43]. Malik et al studied the use of locust bean gum as superdisintegrant in orodispersible tablets and proposed that the mechanism of
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Gum Karaya (other names :terculia, Indian tragacanth, Bassoratragacanth, kadaya, Kadira and katila) occurs as a partially acetylated derivative. It is used as suspending agent, emulsifying agent, dental adhesive, sustaining agent in tablets and bulk laxative [49]. Bansal and Sharma reported the use of modified karaya gum in orally disintegrating tablets of ondansetron hydrochloride and found it can be used as alternative to other conventional disintegrants, where it showed lower time of disintegration, and better availability and price

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