Case Study : Lung Cancer

2501 Words Oct 6th, 2014 11 Pages
Patho Case Study #1
Chapter 16 – Lung Cancer Follow rubric and provide the information
Answer questions 1,4,5,6,10,11,12,14
Utilize your resources such as your text and the Welch library online for UpToDate. Look at the example case for format Case Study Evaluation Criteria I. Overview of Case and Pathophysiology (45 points)
Pathogenesis: The case study identifies a given disease. How does this disease process evolve? Describe the sequence of cellular and tissue events that take place from the time of initial contact with an etiological agent until the ultimate expression of a disease. (25 pts.) (Brittany, Jillian)

Squamous Cell Non-Small Cell Lung Cancer (NSCLC) occurs in about 30% of all Non-Small Cell Lung Cancer cases. (Khan Academy Medicine, 2012) There are two main features of squamous cell NSCLC that distinguish it from adenocarcinoma and large cell NSCLC. Squamous cells contain keratin within the cell and are connected to each other by desmosomes (Khan Academy Medicine, 2012). Squamous cell NSCLC is most commonly found in male smokers who have a cough, airway obstruction, Hilar-adenopathy, mediastinal widening with chest x-rays, and Hypercalcemia (Harold, J. Bruyere, 2009). In order to become cancerous a cell has many molecular changes that can occur including: tumor suppressor gene inactivation, oncogene activation, telomerase lengthening, ability to evade apoptosis, and angiogenesis (Mechanisms in Medicine, 2012). There are a few particular…

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