Castleman 's Disease : What Is It?

Lymph is the name given to the fluid of plasma proteins that escape the circulatory system at the sites of the capillary network and diffuse into the cells around the capillaries. To enable the body to maintain a homeostatic fluid level and pressure, the lymph must be returned to the circulatory system. The way this happens is for the the network of lymph vessels to pick up the fluid which has escaped,

Some of the most common signs and symptoms patients experience with the disease of Lymphedema is swelling and a feeling of “fullness” in their arms and legs. Patients at times have described the loss of flexibility due to the increase in pain. In addition, the inability to wear their clothes, rings, and wristwatches due to the feeling of them being too tight.

If you notice that a lump or swelling of the lymph nodes and it is persistent, a medical check is necessary. If these symptoms are not caused by an infection or another illness, you will most likely be tested for cancer.

Cancers arising from the lymph nodes or other sites of lymphoid tissue are broadly termed lymphomas. This group of diseases is divided into Hodgkin’s disease and non-Hodgkin’s lymphoma. In both conditions, there is a replacement of normal lymphatic tissue by collections of abnormal lymphoma cells.

Buerger’s disease is an inflammatory disorder affecting small and medium sized arteries with unknown etiology and strong association with smoking. It is a difficult disease to treat and abstinence from smoking is must to arrest the progress. Conservative treatments like vasodilators, anti- coagulants, prostaglandin therapy etc. have questionable role. Arterial reconstructive surgery is not feasible usually. Sympathectomy, though widely used works partially or not at all. Progression of the disease invariably leads to amputation. Over the years, the methods and devices have evolved and its indications have been extended to treat fractures and associated complications: nonunion, chronic osteomyelitis, shortened extremity, joint contracture, and

Waldenstrom's macroglobulinemia (WM) is a non-Hodgkin’s lymphoma (NHL) in which the cancer cells make large amount of abnormal cells called macroglobulin. It is also called lymphoplasmacytiod because of the disease resembles to Multiple myeloma (cancer of plasma cells) and non-Hodgkin’s lymphoma (cancer of lymphoma). The WM cells grow mainly in the bone marrow in which causes to have pancytopenia. Symptoms of WM include fever, weight loss (without trying hard), night sweats, and swollen lymph nodes. The common symptom of WM is weakness because of anemia. Neuropathy is numbness and painful sensation (pins and needles) in the legs and feet is also symptoms of WM are that some people experience. Sometimes WM is asymptomatic, and people found out when they had a blood test.

Patients also start to develop small red spots, or telangiectasia’s on the face, mouth, fingers, and in the gastrointestinal tract. A high number of HHT patients will also have or develop artery malformations (AVM’s) in one or ore body organs, where capillaries between arteries and veins are missing. Other common symptoms of HHT include: shortness of breath, exercise tolerance, fatigue, migraine headaches, seizures, abdominal pain, leg swelling, intestinal bleeding, anemia. Also very small proportion of patients have multiple benign polyps in the large intestine, which may bleed or transform into colorectal cancer. A similarly small proportion experiences pulmonary

Cytogenic analysis – Microscopic examination of lymphocytes to look for structural changes or changes in number of chromosomes.

The most common location of this disease is the thorax and neck areas and are more prevalent in males between 30-50 years of age. However,the three patients on which this study is based are women. All three women had localized hyaline vascular type with masses to their neck regions two were removed successfully with no recurring symptoms

Some of the symptoms are dehydration, acidosis, or low level of phosphate in the blood (rickets). Some other diseases are related with the nephropatic syndrome are severe growth of retardation, hyperhidrosis, photophobia, retinal depigmentation, and carnitine deficiency in the muscle tissue. Some fluid ingestion and electrolyte fluids will ease the symptoms, but once the renal failure occurs there is a need for dialysis or kidney transplantation. The diagnosis is made through clinical concept of the Franconi syndrome, rickets develop, failure to thrive, or finding the cystine crystals in the cornea by slit lamp examination. Another way to diagnose it is by the increase of free non-peptide cystine in polymorphonuclear leukocytes or culture fibroplast by 50 to 100

The lymph nodes are spread across the entire body in a careful network. Their job is to prevent infection from spreading from one area to another. They do this through a system of filters that catches the infection in the nodes before it can make it any further in the body. That is why doctors often check for swollen lymph nodes when they are trying to determine a person's health. Usually, once the infection in a person's body is cleared up, any swollen lymph nodes in the region will go back to their normal size. However, there are occasions when they can't do this alone. And that is when lymph care is needed.

Amid these little changes in lymphatic widths, after the NOS barricade in MLV of both matured

General Features of MCC: MCC appears as a nontender red, firm dome shaped nodule that forms in the dermis and immediate subcutis. The tumor consists of densely packed nests or sheets of uniform undifferentiated cells showing the appearance of a so-called small round blue cell tumor. The cells have round to oval nuclei with vesicular to salt-and-pepper chromatin and inconspicuous nucleoli, and the cytoplasm is scant and ill-bordered. Some cases also have relatively irregularly shaped nuclei. The tumor usually has numerous mitotic figures and apoptotic bodies, and

Development of Lymphatic Fluid The lymph framework is practically as broad as that of the blood. The flow of lymphatic liquids assumes a key part in freeing the collection of squanders, poisons, and pathogens. The lymph framework additionally profits by rub, especially in conditions where lymphatic stream is impeded by damage or surgery.

4) What are atypical lymphocytes and how do they appear on: a) blood film, b) graphics plot?