Cause Of Schizophrenia Essay

Schizophrenia is a serious debilitating mental illness in which the victim is afflicted with bizarre delusions and prominent hallucinations. The delusions are profoundly invalid beliefs, and the hallucinations are equally invalid perceptions. There is also a disordering of the reasoning process, disordered emotional expression, and loss of motivation for work and social living. Typically, the illness starts in adolescence or early adulthood and, if untreated, usually worsens with age. (Lickey, Gordon, 1991)

Schizophrenia is classified as a mental disorder that shows profound disruption of cognition and emotion which affects a person’s language, perception, thought and sense of self. The dopamine hypothesis states that schizophrenic’s neurones transmitting dopamine release the neurotransmitter too easily, leading to the characteristic symptoms of schizophrenia. This hypothesis claims that schizophrenics have abnormally high amounts of D2 receptors; receptors that receive dopamine, therefore resulting in a higher amount of D2 receptors binding to the receptors causing more impulses. Dopamine neurotransmitters play a

Schizophrenia is a severe mental illness that usually shows up in adolescence or young adulthood but can be seen in children as young as eight years old. It is a long term mental disorder characterized by a faulty perception of reality, inappropriate actions and feelings, withdrawal from relationships into fantasy and delusion, and a sense of mental fragmentation. It typically involves the breakdown of a person’s relationship between thought, emotion, and behavior. Currently, there are five subtypes of schizophrenia included in the DSM-5; paranoid, disorganized, catatonic, undifferentiated, and residual. Each subtype is characterized by their most prominent symptom. For instance, paranoid schizophrenia is a subtype in which a person experiences

For the past fifty years treatment of schizophrenia has been marked by its basis on the dopamine hypothesis for schizophrenia. However, this model for the disease and its subsequent treatment have left many patients without relief or help in dealing with this disease which has lead to a search for a better model. The dopamine model lacks the recognition of a whole range of symptoms associated with the disease and therefore can not be an accurate basis for treatment. More recently, there has been a shift to the glutamate hypothesis which has been shown to more accurately characterize the wide range of symptoms experienced by patients living with this disorder as well as the possibility in improvements for drug treatments.

The major support and refutation of the dopamine hypothesis has come from the examination of dopamine receptors in these regions of the brain. There are two main types of dopamine receptors, D1 and D2. However, within the category of D2 receptors, there are three subtypes, D2, D3, and D4. (5) Through PET scan analysis of dopamine usage in the brain and post-mordum molecular analysis of brain tissue, researcher were able to determine relative levels of dopamine receptors in patients with schizophrenia compared to non-schizophrenics. Overall analysis of dopamine

Gottesman also supports the genetic link, showing schizophrenia is more common in close biological relatives of a schizophrenic. However genetic explanations cannot account for the patients who have no family history of the disorder. Biochemical factors are used to suggest that schizophrenia is caused by abnormal neurotransmitter activity. The main aspect of this explanation is the Dopamine hypothesis. Schizophrenia has been linked to with high levels of dopamine in the brain.

Schizophrenia is a chronic and severe mental disorder that affects how a person thinks, feels, and behaves. Schizophrenia is not as common as other mental illnesses in fact only about 1% of all people worldwide are diagnosed with it. The symptoms of this disorder can be quiet disabling. Signs of schizophrenia usually appear in late adolescence or early adulthood. It is relatively rare for older adults and children to start developing signs of schizophrenia, but it does happen. The symptoms of schizophrenia can be categorized in three groups: positive, negative, and cognitive symptoms. Positive symptoms are psychotic behaviors not typically seen in healthy people. People with positive symptoms tend to lose touch with some aspects of reality. These symptoms include hallucinations, delusions, thought disorders, and movement disorders. The most common symptoms are hallucinations and delusions. Hallucinations are sensory experiences that occur in the absence of a stimulus and they can occur in any of the five senses (visual, hearing, smell, taste and touch). The most common type of hallucination found in people with

Over the years, experiments have produced evidence to suggest that dopamine plays a role in the development of Schizophrenia (Howes, McCutcheon, & Stone, 2015). Dopamine is a neurotransmitter that is produced in the substantia nigra and ventral tegmental regions of the brain. The belief that dopamine was involved in Schizophrenia arose after multiple studies performed with compounds produced an increase in extracellular concentrations of dopamine (Lieberman, Kane, & Alvir, 1987). The patients that were administered these compounds had similar symptoms to those observed from patients who were diagnosed with Schizophrenia (Lieberman et al., 1987).

Another major problem with the dopamine theory is that it only takes into consideration a single neurotransmitter and neglect the roles of other neurotransmitters in schizophrenia. The findings are inconsistent where some findings proposed that the abnormality causes the availability of dopamine transporters changed, and effect to the increased or decreased of dopamine level (Fusar-Poli, and Meyer-Lindenberg, 2012), while some other findings suggested that there are other neurotransmitter such as glutamine which involved in excitatory response in the brain has played a role in resulting cognitive deficits of schizophrenia (Stone, Howes, Egerton, Kambeitz, Allen, Lythgoe, et al, 2010). These assumptions have allowed researchers to implicate schizophrenia by using another pathway or biochemical mechanism other than dopamine hypothesis or dopaminergic

Researchers favouring the biological explanation look at genetic factors, brain structure and biochemical explanations. Many researchers would suggest that the debate over whether schizophrenia is passed down through genetics is no longer a

Schizophrenia can be passed down thru generations even though there is not a specific gene associated with the disorder. It is considered to be a combination of genes that make a person susceptible to becoming schizophrenic. This information is found mainly thought the study of twins. By having the same genes it can be viewed why genes contribute to the potential of schizophrenia. Even though genetics is a viable factor in the analysis of the cause of schizophrenia there are more supporting factors found in neurotransmitters.

Schizophrenia is a very serious, long-term disorder that affects about 1% of the world’s population. It affects people anywhere from twenty years old, to forty-five years old. It is known to be one of the most disabling diseases in this age group. Schizophrenia can break down a person’s behaviors, emotions, and thoughts. People who suffer from schizophrenia usually show very inappropriate displays of their actions and feelings. Sufferers have been known to hear voices, even when there is nobody around them. They have problems controlling their thoughts, and sometimes blurt out things that are very inappropriate. This paper will outline the biological, social, and psychological

(Kalat, 2012). Bleuler used the term as a means of representing a major psychotic illness

Schizophrenia is a complex disorder of the brain, which is incurable but treatable to live a close to a normal life. There are different types of schizophrenia and they each have different symptoms and affect a person's life in different ways.

There are many causes to Schizophrenia. Many causes are genetics, brain chemistry and structure, and the environment of a human being. Genetically Schizophrenia can run through a family and can be passed on generations at a time. “Individuals with a first degree relative (parent or sibling) who has schizophrenia have a 10 percent chance of developing the disorder, as opposed to the 1 percent chance of the general population.” (Helpguide.org) Identical twins are a good example of this. “If an identical twin is diagnosed with Schizophrenia the other twin is 50 percent more likely to also be diagnosed with the mental disorder (psychcentral.com).” Brain chemistry and structure is another big factor in the cause of Schizophrenia. Neurotransmitters-