What is Lupus? Lupus is an autoimmune disease in which our autoantibodies target self-proteins, known as ANAs. Systemic Lupus Erythematosus (SLE) is understood to be caused by our genetics and the environmental triggers from our everyday lives. There are four different types to this incurable but manageable disease, Cutaneous Lupus Erythematosus, Drug-induced Lupus Erythematosus, Neonatal Lupus, and Systemic Lupus Erythematosus. I will cover all of them, the main focus is on Systemic Lupus Erythematosus
Discussion Cause Systemic Lupus Erythematosus is complex autoimmune disease caused by a combination of genetic, epigenetic, and environmental factors. The body’s autoimmune cells fail to distinguish a diseased cell or foreign organism from its own healthy cells. Consequently, the autoimmune system attacks its own cells causing inflammation in multiple systems including; the kidneys, skin, heart, lungs, hematopoetic, and nervous system. An estimation of 20 – 100 different genetic factors make
associated with SLE is complex and attributed to various factors. These factors include sex, the imbalance of hormones, and ones’ hypothalamus, pituitary, and adrenal axes. Others have said that it is attributed to the cells in your body that are dying, over active help of the T cells in the body, defective B cells, and the shifting of the T helper 1(Th1) to T helper 2 (Th2), which are responsible for the B cells causing them to produce these pathogenic antibodies that cause SLE. (Cambridge, Teodorescu
Diagnosis of lupus is complex. From the appearance of the first symptoms to an adequate diagnosis, on average it takes six years. Women are 10 times more likely to develop lupus than men. African American women aged 45 to 65 have the highest risk of developing lupus (Sacks, J J, 1). SLE accounts for 70% of all cases of lupus. Approximately 10 to 15% of patients with lupus will have a premature death related to lupus (“Lupus Facts and Statistics | National Resource Center on Lupus.”3). The figure1
Lupus: The Cause and Effects on the Human Body Lupus Erythematosus, or Lupus, is a chronic autoimmune disease that causes the human body to attack itself. Autoimmune (meaning “self” immune) diseases result in the body being unable to distinguish between foreign threats and the body’s healthy tissues. Lupus has the potential to range from a mild aesthetic inconvenience to a life-threatening ailment. There is believed to be about five million people worldwide who are living with a form of Lupus (Ginzler
Systemic Lupus Erythematosus aka (SLE) is an autoimmune disease that occurs in most women. SLE causes the immune system to attack the bodies healthy tissues and organs and this can be very dangerous to the body depending on the severness of the disease. During this process the human body produces autoantibodies that begin to attack the body thinking as if it was foreign invaders. (This picture shows the autoactive body cells attacking healthy skin.) Biology of the Diesease During SLE, the body’s
Lupus nephritis Lupus nephrirtis is more commonly known as “lupus” is an inflammation of kidney caused by Systemic lupus erythematosus (SLE) , Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the loss of immune tolerance to nuclear self-antigens. The deposition of autoantibodies along the glomerular basement membrane results in immune complex-mediated glomerulonephritis generally characterized by like malar rash, discoid rash, photosensitivity, oral ulcers, nonerosive
Zagazig University Faculty of Medicine Clinical Pathology Department Association of STAT4 Gene Single-nucleotide Polymorphism with Systemic Lupus Erythematosus Thesis Submitted for partial fulfillment of M.D. degree in clinical pathology By Marwa Abd El-Monem Mohamed Ateya MB.B.CH. Ass .lecturer of Clinical Pathology Faculty of Medicine Zagazig University Prof. Dr. Lamiaa Abd Al-wahab Mohammad Professor of Clinical Pathology Faculty of Medicine Zagazig University Prof. Dr. Asmaa
Lupus is a chronic inflammatory disease that occurs when your body’s immune system attacks your own tissues and organs. The inflammation caused by lupus can affect many body systems including the following: joints, skin, kidneys, blood cells, heart and lungs. Lupus occurs more frequently in women than in men. There are four different types of Lupus that exist. They are Systemic lupus erythematosus, Discoid lupus erythematosus, Drug-induced erythematosus, and Neonatal lupus. The most common and
Millions of people around the world suffer from incurable, autoimmune diseases. Even with the tremendous advancement in medical field, there are many questions unanswered. More and more diseases of unknown cause are being evolved every now and then, which are threatening to the mankind. Systemic lupus erythematosus (SLE) is a classic example of such a disease. SLE is a chronic, often life-long, autoimmune condition, ranging from mild to severe in severity. SLE may affect many organs in the body,