Causes And Symptoms Of Metastatic Bone Cancer

3361 Words Mar 23rd, 2015 14 Pages
Metastatic bone cancer is a result of primary tumour cell spread, through direct and local invasion, and vasculature or lymphatic circulation. It is a common feature in solid tumours formed in lungs, breasts, thyroid and prostate along with multiple myelomas and renal carcinomas. One of the major signs and symptoms for patients with bone metastases is localized pain, which is often difficult to control and can be quite sever. This paper will discuss the process of metastasis, the aetiology and pathophysiology of bone metastases, and the changes that occur within bone due to metastatic spread. It will outline bone metastases signs and symptoms, and discuss radiotherapy treatment options based on patient assessments, focussing on supportive and palliative care.
Metastatic spread
Metastasis of a primary cancer usually involves local and/or direct invasion, intravasation and circulation. Initially a tumour in situ is contained within that tissues basement membrane, feeding off local blood supply and proliferating locally. As the tumour grows, it will follow the path of least resistance, pushing through the primary tissues membrane into the extracellular matrix, and invading nearby normal tissue in direct invasion, shown in figure 1.

Figure 1. Tissue membrane…
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