Causes And Treatment Of Biofilm Formation

2149 Words Nov 12th, 2014 9 Pages
Abstract: Biofilm formation poses a universal complication to all implantable prostheses or devices in the human body. Medical costs rise substantially with biofilm formation and may lead to further life-threatening conditions. Researchers are looking into the anti-bacterial efficacy of different surface-coatings such as metals, polymers, nanoparticle texturing, and composites of each. The method through which bacteria adhere and/or aggregate is different across each surface-coating. While each have shown significance in the reduction of biofilm production in vitro, researchers have yet to perform effective in vivo experiments to confirm durability, adhesion specificity, cytotoxicity, and overall efficacy. It has been supposed that multifaceted “smart” surface-coatings are optimal for inhibiting biofilm production. However, there are still many complications inherent in both the smart-coating’s structure and chemistry that renders it unfeasible as a long-term solution.

Introduction: Bacterial infections are the main source of complications for implanted devices. It is said that operation rooms today are contaminated within the first hour of operation. This leads to an estimated 2.5% of periprosthetic joint infection (PJI) from common implantations such as primary hip and knee arthroplasties and 20% of revision arthroplasties [1]. In addition, the cost of treating infected prosthetic joint replacements amounts to over $50,000 per occurrence [2]. These outstanding…
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