Causes And Treatment Of Sepsis

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REVIEW OF LITRATURE The term “sepsis” has been around since prehistoric times. Hippocrates presented the word sepsis 2400 years ago to represent a condition where an overwhelming infection leads to tissue breakdown with rotting, foul odour, and disease. The ancient Roman scholar and writer (116 BC–27 BC), Marcus Terentius Varro mentioned that “small creatures, invisible to the eye, fill the atmosphere, and breathed through the nose cause dangerous diseases.” In the early 1990s at a conference convened by the American College of Chest Physicians and the Society of Critical Care Medicine modern definitions of “sepsis” were termed in detail. At that time, “sepsis” was described as a systemic response to a physiologic insult including infections and other etiologies that lead to the development of further organ injury, ultimately culminating in multiple organ dysfunction syndromes. The word “bacteraemia” is used when bacteria are isolated from the blood whether clinical symptoms are present or not while the words “sepsis” or “septicaemia” is used for the isolation of bacteria in blood in combination with clinical symptoms and signs of infections. Neonatal sepsis, also named “Sepsis neonatorum”, represents to a group of physical and laboratory findings that occur in response to invasive infection within the first 30 days (neonatal) of life. Criteria for neonatal sepsis should include documentation of infection in a newborn infant (0-28days) with a serious systemic illness in
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