Causes And Treatments Of Pancreatic Cancer

Pancreatic Cancer is cancer of an organ in the human body called the pancreas, which is located behind the lower part of the stomach. The function of this organ is to secrete certain essential enzymes to digest food and also secrete hormones to metabolize sugars such as insulin and glucagon (Mayoclinic). People get pancreatic cancer when the cells of the pancreas develop genetic mutations; and these can form in both the exocrine and endocrine cells of the pancreas, but exocrine tumors are more common than endocrine tumors. Because this cancer spreads very quickly throughout the body and the symptoms of the disease don’t usually appear until the cancer is at an advanced stage, it is a leading cause of death

What the cancer did, In 2015 more than 48,000 people were infected with pancreatic cancer. in America pancreas is almost in the top 10 most common cancers in the world. pancreatic cancer is a disease in the tissues of

     Several tests can be run once symptoms are noticed to earmark the disease with a proper diagnosis. Some of the tests include; a biopsy of the tumor, X-rays, a CT scan, a skeletal survey, bone scans or bone marrow aspiration (fluid sample) and biopsy (tissue sample). Once diagnosed, the treatments begin to hinder any advancement the cancer would or could make. Possibly removing the cancer completely through surgery is a possibility, while others include chemotherapy, radiation treatment, and bone marrow transplantation. Many times these treatments can be used concurrently with one another.

There is another classification of pancreatic tumor help in decision making of management. This classification depends on the possibility of surgical removal of the tumor: in this way, tumors are judged to be "resectable", "borderline resectable" or "unresectable" (American Cancer Society, 2014).

According to Professor John Neoptolemos, "There are approximately 7,000 new cases each year - but it is one of the most lethal cancers." The main reason for the low survival rate from pancreatic cancer is due to its difficulty in finding this cancer early. By the time a person has symptoms, the cancer has often reached a large size and spread to other organs. Because the pancreas is deep inside the body, the doctor cannot see or feel tumors during a routine physical exam. There are currently no blood tests or other tests that can easily find this cancer early in people without symptoms. Tests for certain genes in people with a family history of the disease can help tell if they are at higher risk for cancer. There are some new tests for finding pancreatic cancer early in people with a strong family history of the disease, but these tests are complicated and expensive. Some symptoms of pancreatic cancer include jaundice, a yellow color of the eyes and skin caused by a substance buildup in the liver, pain in the belly area or in the middle of the back, significant weight loss over a number of months, loss of appetite, digestive problems including nausea, vomiting, pain that tends to be worse after eating, a swollen gallbladder that is enlarged, blood clots that form in the veins or cause problems with fatty tissue under the skin, and diabetes. If the doctor has any reason to suspect pancreatic cancer, certain tests will be done to see if the disease is really

Diagnosis of pancreatic cancer leads to Principal Sandy Shore to declare his resignation at the Papillion-La Vista South High School graduation today.

Before the discovery of insulin, diabetes was a feared disease that most certainly led to death. Doctors only knew that sugar made the condition worse and that the most effective treatment was to put the patients on very strict diets where the amount of sugar intake was kept to a minimum. At best, this treatment could buy patients a few extra years, but it never saved them. In some cases, the harsh diets even caused patients to die of starvation. During the nineteenth century, observations of patients who died of diabetes often showed that the pancreas was damaged. In 1869, a German medical student, Paul Langerhans, found that within the pancreatic tissue that produces digestive juices there were clusters of cells whose function was unknown.

Pancreatic cancer is the cancer that appears quickly and many die just as quick. Pancreatic cancer is the least known cancer to the medical world; puzzling doctors because most are not sure what diagnosis to look for. However, the risk factors include smoking, diabetes, and obesity. Studies show that pancreatic cancer has a higher percentage in the African American community due to environmental risk factors (John Hopkins Pathology, 2012).

of diabetes; 5 million cases of heart disease and more than 400, 000 different case of cancer

The pancreas is an organ mainly involved in process as digestions and the synthesis of hormones, and as all the others tissues in our body, it can develop cancer. Actually, pancreatic cancer is one of the deadliest types of cancer, either because of the symptoms that only appears at a late stage of the disease, the hard diagnosis and the high chances of metastasis.The symptoms associated with the pancreatic cancer are not specific, such lack of appetite, abdominal ache and weight loss. The diagnosis of pancreatic cancer is hard because the pancreas is located in not favorable position for exams to scan and detect its presence. Pancreatic cancer can also metastasize to other tissues, but mainly to liver tissues and it actually happens before

A healthy pancreas pumps out insulin in exact doses, masterfully managing the level of glucose so it never raises too high, which could lead to various complications; or too low, which could lead to a coma or kill someone on the spot. My pancreas, however, no longer makes insulin; it can’t. For reasons no one fully knows, my own immune system turned against itself and killed off the cells that produce

This year, an estimate of 53,070 adults, have been or will be diagnosed with pancreatic cancer. (27,670 men and 25,400 women). Pancreatic cancer is the ninth most common cancer in women. Pancreatic cancer should have the most attention because doctors still don’t know how to diagnose this type of cancer yet. The main problem is cost-effective screening tests that easily and reliably find early-stages of pancreatic cancer in people, sometimes show no symptoms.Often “times it is” not found until later stages when the cancer can no longer be surgically removed and has spread from the pancreas to other parts of the body. ("Pancreatic Cancer: Statistics", 2017)

Diabetes is caused by the blockage of insulin receptors. This disease slowly breaks down the cardiovascular system and eventually leads to death. Cancer is the rapid growth of cells and causes tumors to form. These tumors take over organs of the infected individuals body. Overtime the tumor will stop the organ from functioning and will cause death.

KRAS is mutated in roughly 90% of tumors and there remains no clear inhibitor to downregulate this mutant oncogene (17). The KRAS mutant acts within the EGFR/ERK pathway which was previously supported to be linked to the expression of FASN. Many inhibitors have been developed to downregulate the downstream effects of the mutated KRAS (16). It has, however, never been attempted to use RAS inhibitors and FASN inhibitors in combination. Therefore, we hypothesize that combinatorial inhibition of FASN and lipid kinases inhibitors (PI3K) or the inhibition of FASN and HSL lipid production will upregulate pancreatic cancer cellular apoptosis and downregulate the RAS and PI3K pathways.

Another study conducted by researchers at Tel Aviv University—published in Nature Communications—hones in on the inverse correlation between the expression of oncosuppressor microRNA and a pre-established oncogene—a cancer development gene. The study says that this explains prolonged survival of pancreatic cancer, and the findings may very well yield future cultivation of effective drug cocktails for fighting not only multiple cancer types but also several other mortal diseases.