Causes Of Crohn's Disease

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For instance, Crohn’s disease(CD) is a chronic relapsing inflammatory bowel disease (IBDs), which affect the various areas of GI tract (from mouse to anus) and lead to abdominal cramps, weight loss, diarrhea, fever and the other symptom. According to the survey, Crohn’s disease was found to be more common in developed industrialized countries than less developed tropical countries because people who lived in developed areas have less chance of exposure to helminthes. Therefore, although the cause of Crohn’s disease is not fully understood, but it is consider to be related to environmental, genetic factor and autoimmune reaction. Medically speaking, Crohn’s disease is classified as an autoimmune disorder. Usually, there are many harmless and…show more content…
After a few months, T. suis dies and cause no symptom, meanwhile six patients out of seven achieved remission of symptom. In 2005, in his second study, he gave a dose of 2500 T,suis egges to 29 patient who suffering from Crohn’s disease every three weeks. After 24 weeks, 79% of them got relief from disease. The important thing is that there is no any negative effect was appeared. The mechanism of this helminthic therapy can be involved in TH1/Th2 balance hypothesis. As we known, T helper cells have the function of recognizing foreign pathogen that is important part of the immune system. Besides that, they can be classified as Th1 cells and Th2 cells which participate in different immune response respectively.Th1are involved in response with viruses and bacteria. Th2 cells are related to allergy response, and produce antibodies against toward parasites as well. When Th1 cells of the immune system dominate in this Th1/Th2 balance, the activity of Th2 can be inhibited. Because CD is a Th1dominat disease, helminthes can promote Th2 immune response while suppress Th1 immune…show more content…
Allergic asthma is considered to be autoimmune disease because immune system attacks allergen and releases immunoglobulin E (IgE) that induces inflammation and obstruction of the airway. In 2004, David Pritchard found that hookworm larvae infection can reduce airway responsiveness in patients with allergic asthma. In 2006, during his second clinical trial, there are 15 participants received a dose of10 hookworms, and the other15 participants received placebo. After six weeks, the result shown that 15 worm recipients experienced a low inflammatory response. This indicates that their immune system can be controlled and suppressed by
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