Causes Of Crohn's Disease

Crohn’s Disease was named after an American gastroenterologist, Dr. Burrill Bernard Crohn, in 1932. He and his colleagues discovered an abnormal pathogen, Mycobacterium paratuberculosis while studying a related disease, ulcerative colitis, which belongs to a larger group if illnesses called Inflammatory Bowel Disease (IBD). The discovery was made while studying the effects of ulcerative colitis in cattle and noticing the similar characteristics in humans. The infections had an abnormal response with the body’s immune system in both the cattle and humans.

3. Describe the factors that are believed to contribute to the etiology of Crohn’s disease.

Cells move from the blood into the intestines and produce inflammation which is a normal immune system response. The inflammation does not subside, leading to chronic inflammation, ulceration, thickening of the intestinal wall, and eventually causing patient symptoms.

“I will keep fighting,” is what I remind myself as soon as the sun peaks up. Many people are not aware of Crohn’s, nor did I when I was diagnosed at age 8. I have learned Crohn’s is not just a simple disease; it changes lives. My experiences with Crohn’s built me into a stronger person, both physically and mentally. Crohn’s caused me to grow up rapidly, faster than my fellow classmates. Entering high school with Crohn’s had been a remarkably frightening experience, yet at the end of each day, I decided I was not going to allow my disease to define who I am. So when you walk through those high school doors, remember: be who you are, not what Crohn’s makes you. Participate in activities you loved to do before you got Crohns- just modify them.

According to the text, "Wellness has been defined as purposeful, enjoyable living or, more specifically, a deliberate lifestyle choice characterized by personal responsibility and optimal enhancement of physical, mental and spiritual health.

Crohn’s was first described by a man named Dr. Burrill B. Crohn in the year 1932 (Crohn’s & Colitis Foundation of America, 2016). This disease is described as an abnormal inflammation of the intestine walls, typically happening in the ileum, which is the lower part of the intestine or the small bowel, as you can see in Figure 1. Although, Crohn’s can affect any part of the gastrointestinal (GI) tract (Genetics Home Reference, 2016). Crohn’s is relatively an uncommon disease, there are about 33,000 new cases a yea but it doesn’t discriminate when it comes to age or culture. There is not a certain age or gender one has to be to develop Crohn’s, but it is generally found in male and females from North America or Western Europe, ages 15-35 years

Crohn's Disease affects an individuals immune system because your body is attacking itself by creating antibodies that work against itself. When you have Crohn's disease your immune system overreacts to food and bacteria in the intestine that a person without Crohn's diseases body would not react to. White blood cells in the intestine cause chronic inflammation. Crohn's disease can affect any part of the GI tract but most likely found at the end of the small intestine, the ileum. The inflammation can occur through the entire thickness of bowel wall. Events that occur with the inflammation are persistent diarrhea, rectal bleeding, abdominal pain, constipation, weight loss, sweating, and loss of appetite.

This review will explain Crohn’s disease and Ulcerative colitis, two types of inflammatory bowel disease that affect millions of people. These diseases are chronic that affects certain parts of the intestine gastrointestinal tract. People who has this disease are troubled with a variety of side effects that they will have to live with for the rest of their lives. To this day, there are no medical cure for these diseases, however there are several treatment options that are helpful. These diseases are still being studied for researchers to fully understand the causes, possible preventions, and cure for IBDs. Countless researches and studies are still under development, there have been many discoveries thus far, but nothing concrete.

Crohn's disease is a disease that presents similarly to food poisoning in that it causes imflammation of the digestive tract in an individual. During the development of this disease the body becomes hypersensitive to the bacteria found in one's gut, and thus these beacteria are the cause of the inflammation caused by the immune system attacking the bacteria in a person's stomach. Therefore, it is an autoimmune disease. The only known way to combat crohn's currents is corticosteroids, which supress the immune system.

In order to explain the significance of oral aphthous ulcers in Crohn’s disease, we need to first look at the pathophysiology of the disease itself.   Crohn’s disease is a relapsing inflammatory bowel disease which can affect the entire gastrointestinal tract. The cause of the disease is not well understood. However, it is believed that the inflammatory response is mainly due to a combination of genetics, an over-reactive immune response, and environmental factors. These factors lead to an inappropriate inflammatory response against enteric bacteria (Bartels et al., 2013).  In Crohn’s disease, there is an abnormal and exaggerated response to bacteria within the gut.  As we have learned in previous lectures, an inflammatory response is a defense

Before I start explaining how terrible this disease is, I chose it because I am currently suffering from it. I have had Crohn’s since 2012 and have gone through three colonoscopies and endoscopies. My Gastroenterologist, in the beginning, tried two treatment plans, which did not work. The third treatment plan, which is Humira injections, seems to be working so far. Crohn’s Disease is an autoimmune disorder that causes inflammation in the bowels and digestive tract; the inflammation can be in different locations of those areas. The inflammation is thought to be the body making too much of certain proteins. The disease can affect anyone at any age. Right now, doctors feel that it can be brought on both by the environment or passed down through

There are currently two tumour necrosis factor alpha (TNFα) antagonist available on the PBS for treatment of IBD: infliximab and adalimumab.1 Another biological is vedolizumab which is a gut specific humanised monoclonal antibody that binds to and inhibits α4β7 integrin expressed on the surface of lymphocytes preventing their binding to mucosal addressin cell adhesion molecule-1 expressed on vascular endothelial cells within the GI tract.16 Blocking this binding prevents lymphocyte migration into intestinal tissue thus reduce inflammation.16 Lastly, the most recent approved biological agent by PBS is

I was right, I did change because of Crohn’s Disease and my life will never be how it was before, but with time I came to realize that this was for the best. Crohn’s Disease was one of the biggest eye openers in my life. This illness allowed me to develop a deeper understanding of life and gain the strength to mature mentally, emotionally and intellectually. Being chronically ill taught me that if I can overcome the physical and emotional challenges of Crohn’s Disease, then I could overcome anything. I quickly transformed any paralyzing fears and insecurities about having being ill into a determined drive for success. I maintained a 3.91 GPA whilst I was either working or interning, even through times of flare-ups.

This essay will focus on Crohn’s disease and pathological changes that may occur in the small intestine as a result of the inflammatory process and discuss the scientific reasons for the possible treatments relating these to pathological processes.

Both Crohn’s disease and ulcerative colitis patients have high levels of CD4+ T lymphocytes in their mucosa. CD4+