Causes of and Treatments for Amyotrophic Lateral Sclerosis

ALS is also known as Amyotrophic Lateral Sclerosis is a disease in which the brain, nerves, and spinal cord deteriorate. It attacks every part of the body except the brain. Causing major body malfunction along with muscle weakening. Which includes lack of strength, the ability to move arms, legs and body, eventually you lose the ability to breathe. The average time of life after being diagnosed is two - five years. It was believed to be inherited or maybe an infection. After years of research scientist have found a major

Amyotrophic meaning, “no muscle nourishment” in Greek, lateral meaning where the neurons are in the spinal cord, and sclerosis meaning “scarring.” ALS, often known as “Lou Gehrig’s Disease,” named after the New York Yankee who first brought awareness to the disease in the late 1930’s, is a neurodegenerative disease, which affects the neurons in the brain. The nerve cells in the brain and spinal cord that are responsible for sending and receiving motor signals progressively die off, causing the deterioration of simple motor skills in patients with ALS, such as walking, talking, and eventually speaking and breathing, however thinking is not affected by ALS. Early symptoms cause the person to slowly lose mobility of limbs, but in a matter of a few years, the person loses the mobility of most of their body and will eventually lose the ability to eat and breath, which will ultimately cause death. ALS deteriorates the patient's body, however does not affect the patient's state of mind or sanity while the rest of the body shuts down. People usually get ALS between the ages of 40 and 70. However, there is a growing trend where athletes are getting ALS in their thirties. ALS can be contributed to genetic predisposition, which means that the gene that is responsible for ALS is already in the person’s DNA. In recent studies, however, it was observed that individuals who have had suffered multiple concussions or any other head trauma are

ALS (Amyotrophic Lateral Sclerosis) or Lou Gehrig’s Disease is a classified as a degenerative neurological disorder that inhibits motor neurons in the spinal cord and brain to function properly. This disease eventually results in paralysis and imminent death over a period of time. ALS patients have anywhere from a few months, to a couple years to live after diagnosis since their nervous systems are slowly destroyed, rendering the body useless, and sustaining life impossible.

ALS is more commonly known as Lou Gehrigs disease. The progressive disease poisons the nervous system by a chemical that is released after a blow to the head; this chemical is known as Tou. Tou is released into the brain after a blow, poisoning the nervous system causing body muscles to shut down.

There are 20,000 new cases of ALS diagnosed each year in the United States. This yields an incidence of 3 per 100,000 (Brown, 2006). There is no known cause for ALS in 95% of patients; however, 5% have an identifiable genetic mutation (Elman, 2016). The disease can present in individuals less than 30 years of age, but peaks between 40 and 60 years of age. Before the age of 65, more diagnoses are made in men; after the age of 65, gender incidence is equal. There is no clear-cut ethnic or racial predisposition in ALS (Ricks, 2016). The lifespan is approximately 3-4 years after diagnosis. However, in 10 % of

ALS is a disease which is prevent the body from producing normal things. Most people who develop ALS are between the age of 40 and 70, with an average age of 55. The athletes is between 20 and 30. “Lou Gehrig, he was a baseball player, he had ALS in his 30 years old”. “Dou Revie, he was a football player, he had ALS when he was 29”. People who have ALS gradually become more disabled, they can’t walk, speak, eat and anything in

Amyotrophic Lateral Sclerosis also known as ALS or Lou Gehrig Disease, it's a disease that affect the neurons in the brain and its ability to communicate with other neurons leading to complications to the spinal cord. This disease affects the victim in various ways it's a progressive disease meaning it starts off slowly

“A-myo-trophic comes from the Greek language ‘A’ meaning no or negative. ‘Myo’ refers to muscle, and “Trophic” means nourishment-’No muscle nourishment’... ‘Lateral’ identifies the areas in a person's spinal cord where portions of the nerve cells that signal and control the muscles are located.” (“What is ALS?”). Literally, Amyotrophic lateral sclerosis means no muscle nourishment in the spine. In this disease, nerve cells in both the brain and spinal cord slowly die over a period of time. The cells, referred to as motor neurons, control the muscles throughout the body, resulting in death or paralyzation as they degenerate. At any given time, ALS can strike anyone. It is not contagious, however, in about 10% of cases, ALS runs in the family making it somewhat hereditary (“What is amyotrophic lateral sclerosis?”). “The incidence of ALS is two per 100,000 people” (“Facts You Should Know). Most of the time, Lou Gehrig’s disease (ALS), acts on middle-aged and older adults, however there have been noted cases of patients much younger. Considering that a friend or family member can be diagnosed with this horrible disease, everyone should pitch into ALS charities in hope to find a

The National Institute of Neurological Disorders and Stroke have identified over 12 genetic mutations as the cause in some familial cases of ALS. The research on ALS is continually resulting in new factors that may be the cause of ALS, including environmental factors and even possibly a “genetic predisposition”. (www.ninds.nih.gov/disorders/amyotrophiclateralsclerosis/detail_ALS.htm) Personally speaking, when I told my mom about the ALS Ice Bucket Challenge, she told me that ALS was what my great grandma had died from. I had known that my great grandma had died from some disease, but I didn’t know that it was ALS. Unfortunately for my great grandma and the others suffering from ALS, there has not been a cure found yet for ALS. There is one FDA approved drug for ALS called riluzole (Rilutek). Riluzole helps to reduce the damage to the nerves that are being attacked by the disease. While Riluzole can’t reverse the damage that has already been done to the nerves and muscles, it can extend the amount of time before the person needs respiratory support and help with difficulty

As many as 30 thousand Americans are currently living with or have been diagnosed with ALS in the United States. ALS is a life threatening disease that scientists have yet to discover treatments for, but as of right now, ALS can not be treated. ALS can be hard to understand, many wonder how does one get ALS? What are the symptoms ? How is ALS diagnosed? Treatment options, and what is the prognosis of the disease?

Some things that can cause ALS is a genetic mutation in the SOD1 gene when a baby is born. It can also develop over time. There is no known cure but some things that can help are medication and physical therapy. In most cases, patients die within 2-5 years of being diagnosed.

Amyotrophic Lateral Sclerosis (ALS), or Lou Gehrig’s disease, is a neurodegenerative autoimmune disease. This means that the neurons ( nerve cells of the brain and spinal cord), particularly the ones that control voluntary muscles (motor neurons), degenerate and die. Naturally, motor neurons in the brain send signals to the motor neurons in the spinal cord, which in turn, sends signals to the muscles. However, the degeneration and death of these neurons (upper and lower motor neurons) doesn’t allow the body to transmit signals to permit the movement of muscles. This eventually causes the weakening of the muscles, and the brain’s loss of controlling voluntary muscle movement. By this, people lose their ability to speak, walk, and breathe.

ALS is inherited in five to ten percent of cases, while other cases just seem to appear randomly (Learn About ALS 2014). Some believe that the nerve cells that control movement just gradually die off. It is also said by doctors and scientists that this condition is the result of a gene mutation. Others, on the other hand, believe there is a chemical imbalance where there are higher than normal levels of glutamate, which is a chemical messenger in the brain around the nerve cells in their spinal fluid (Learn About ALS 2012). Earlier in class, we established that glutamate is a salt or ester of glutamic acid, and too much glutamate is known to be toxic to some nerve cells. Some cases could be a result of a disorganized immune response where the immune system begins attacking normal cells, leading to the death of nerve cells. When a body’s own cells begin attacking its normal cells, it’s almost guaranteed that the body is at risk for shutting down. There could also be some sort of protein mishandling; mishandled proteins with the nerve cells may lead to gradual accumulation of abnormal forms of these proteins in the cells, eventually causing nerve cell death. Some scientists believe that they have found genetic links related to acquiring this disease, but not legitimate cure has been settled on or established (Learn About ALS

ALS is one of the most common neuromuscular diseases worldwide (Amyotrophic Lateral Sclerosis Fact Sheet).There are three different types of ALS causes there is, familial, sporadic, and guamanian. Familial is 5-10% , sporadic is the most common which is 90-95% of all ALS causes and guamanian is rare variant. Guamanian is very similar to ALS almost the same and it happens because of something toxic that they are eating which messes with their nervous system (ALS[Lou Gehrig’s Disease]). It is also a disease varied with etiology characterized by rapidly progressive in weakness in the muscles.

ALS is named for its underlying pathophysiology, which is “amyotrophy” referring to the atrophy of muscles fibers, which denervated as their corresponding anterior horn cells degenerate. “Lateral sclerosis” refers to the changes seen in lateral columns of the spinal cord as upper motor neuron axons in these areas degenerate and are replaced by fibrous astrocytes. ALS affects motor neurons at two or more levels of the motor neuron network supplying multiple regions of the body and as a consequence, the communication between the neurons and muscle is lost, promoting progressive muscle weakening. That is, ALS affects lower motor neurons that reside in the anterior horn of the spinal cord and in the brain stem, corticospinal upper motor neuron