Cell Biology Lab Report

1043 Words Feb 19th, 2018 4 Pages
Cells have the ability to attach or adhere, migrate and spread on a variety of glycoproteins located outside the cell, this occurs due to the presence of specific cell surface receptors, and example being integrins. 1 Integrins, as is again suggested by Akiyama, are non-covalent, heterodimeric glycoproteins that exist in 3 classes and are made up by an alpha and a beta subunit.1 External Structures are linked to the actin cytoskeleton of a cell by integrins. The part of the integrin, which is located in the cytoplasm binds to adaptor molecules that connect the acting filaments inside the cell, while the “external” part of the integrin, binds to other molecules or ECM’s on the surface of other cells. 2 For a cell to form a junction to another cell the external integrins must adhere to other molecules in other cells and this is achieved by assembling a large cytoskeletal apparatus around the molecules that facilitate the adhesion. There are several types of structures that result from cell adhesion, like a desmosome, adherens junction, tight junction, gap junction and hemidesmosome, all illustrated in Image 1 below. 3

In the present, cell-matrix interactions including cell adhesion and the important part that integrins play in it, is the focus of…

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