Cell Proliferation And The Control Of Cellular Function

1228 WordsSep 30, 20165 Pages
1. Introduction Babesias are tick-transmitted hemoprotozoan parasites belonging to the phylum Apicomplexa. These parasites are etiological agents of babesiosis that infect a wide spectrum of mammals thereby causing major health and economic problems in the livestock industry throughout the world. Babesia bigemina is one of several Babesia species known to cause bovine babesiosis. The disease is clinically manifested by anemia, fever, hemoglobinuria, and the presence of parasites in the host erythrocytes (Homer et al., 2000). The 70 kDa heat-shock proteins (HSP-70s) are intracellular proteins found in all organisms. HSPs play important roles in cell proliferation and the control of cellular functions (Lindquist, 1986). Heat shock proteins (HSPs) are known as stress proteins because various forms of stress enhance their transcriptional activation and biosynthesis (Lindquist, 1986). As many bacteria and parasites produce HSP-70, the protein serves as an antigen for bacteria and parasitic pathogens (Erol et al., 1999). Moreover, HSP-70 might play important roles in survival and proliferation of pathogens, such as Schistosoma, Plasmodium, Trypanosoma, and Leishmania within the host (Lindquist, 1986). Many pathogens encounter sudden temperature shifts during the transmission from the vector to a host. Hsp-70 assists the parasite in adapting to a new host environment and is known to have a chaperone function, forming complexes with a diverse array of cellular proteins and peptides
Open Document