Chemical Surveillance Program For Leukemia

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Benzene Exposure – Leukemia in Factory Workers Examined

As part of an occupational surveillance program for leukemia from excessive benzene exposure 1,832 factory workers were screened using a new diagnostic test. It was determined of those exposed, 214 tested positive, 29 tested negative and 90 non-exposure tested positive. With the use of a contingency table we will evaluate the measures of validity of the screening test used.

In the study of the association between benzene exposure and leukemia causality has been established using the Bradford Hill criteria for two specific agents: Ionizing radiation and benzene. Evidence has been established that high daily exposure to benzene in both a time-dose relationship and with dose and response with specific types of such as AML leukemia (Pagano et al., 2006). However, it has been noted by Pagano et al., that results on the environmental factors contain inconsistent results due to the design of the study, uncontrolled bias, and the variance in the populations at risk (2006). Environmental factors such as socioeconomic status, alcohol consumption, and smoking are known contributors to the development of leukemia (Pagano et al., 2006). It’s been observed that occupational exposure to industrial hazards is significantly more frequent overall in populations from lower socioeconomic backgrounds (Nisse et al., 2001). A complete background of study participants would be crucial in evaluating the causative
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