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Chemistry Of Reverse Micelle Based Coatings

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More recently, a reverse micelle based polyacrylate coating method was undertaken to obtain various functional nanorods [24]. The micelle based coating was shown to be very versatile as the coating produced water soluble GNRs without particle aggregation. This coating developed could absorb a variety of functional groups including primary amines, ethylene glycol and fluorescein. This makes them much more suited for biomedical applications. This more recent study, although not highly cited does make progress in the GNR uses in biomedical applications and I believe should stimulate further investigation for this technique. Research conducted by Castellana and team in 2011, studied the label-free biosensing with lipid-functionalised …show more content…

This is exactly what Shen and co-workers [29] did in 2013. They found that the silica-coated GNRs had both a significant potential in both photothermal therapy and drug delivery to tumorigenic regions. Of all the shapes of Gold nanoparticles, GNRs present the most ideal Near Infrared absorption cross section [30] and the highest thermal transmission efficiency [31]. Mackey, M.A and co-workers [32] did research determining what the most effective size of GNRs are for use in thermal phototherapy. They did this by comparing the plasmonic properties and efficiency of GNRs as photothermal contrast agents for three different size GNRs. The three-different size GNRs used were 38x11nm, 28x8nm and 17x5nm. What the results of the study showed was that the 28x8nm GNRs were the most efficient in plasmonic photothermal heat generation. This probed further analysis using in vitro experiments. This experiment compared the same three size GNRs and their ablation of human oral squamous cell carcinoma. The 28x8nm GNR was the most effective size nanorod. This size GNR displayed the best compromise between the absorption of Near infrared radiation and the size of the electromagnetic field around it. This sized nanorod had an electromagnetic field that extended far enough from the particle surface to the target cells to allow for field coupling. Whereas the larger GNRs showed to scatter too much of the energy rather than absorb it and the smaller

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