Chikungunya Virus

876 WordsApr 14, 20154 Pages
In our world, in every ecosystem there are a millions of different types of viruses that exist. In this paper we are going to talk about one specific emerging arbovirus called Chikunganya virus. About thousands of people have been affected by Chikungunya virus throughout the world. During the years of 2005 and 2006, the virus altered over a millions of people in the Africa, Asia and the Indian subcontinent. Now, Chikungunya virus have spread to Europe, South American and North America. Chikungunya is a viral disease that is spread by mosquitoes. There are two type of mosquitos that spread this disease that we will talk further into in this paper. There is no signs or researches that the virus can be passed on or spread by contact from…show more content…
The other polyprotein is the structural polyprotein, consisting of five proteins which are a capsid, E3, E2, 6K and E1. In structural polyprotein, The E1 and E2 glycoproteins are expected to form heterodimers that associate as trimeri spikes on the viral surface covering the surface evenly. Chikungunya virus is a small (about 60–70 nm-diameter), spherical, enveloped, positive-strand RNA virus (see figure 1). Early 2006, the complete sequence of a chikungunya isolate from Reunion Island was made available through NCBI/ GenBank accession no. DQ443544.1. The virion consists of an envelope and a nucleocapsid. The chikungunya virus genome is 11,805 nucleotides long and encodes for two polyproteins – the non structural polyprotein consisting of four proteins (nsP1, nsP2, nsP3 and nsP4) and the structural polyprotein consisting of five proteins (Capsid, E3, E2, 6K and E1) (see figure 2). The 5’ end of the RNA molecule is capped with a 7-methylguanosine while the 3’ end is poly-adenylated. A subgenomic positive-strand RNA referred to as 26SRNA is transcribed from a negative-stranded RNA intermediate. This RNA serves as the mRNA for the synthesis of the viral structural proteins. Alphaviruses have conserved domains that play an important role in the regulation of viral RNA synthesis. These domains are found at the 5’ and 3’ ends as
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