Chlamydia Trachomatis : The Most Widespread Bacterial Agent Of Std All Over The World
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Pathophysiology of Chlamydia
Chlamydia trachomatis is the most widespread bacterial agent of STD all over the world. Genital serovars infection results to the complications including infertility as well as pelvic inflammatory disease. It should be noted that the Chlamydia trachomatis comprises the trachoma serovars which are the primary cause of avoidable blindness globally. Studies indicate that Chlamydia pneumoniae results in the airway disease, and it has been found in some situation of atherosclerosis (Barber, 2013).
Though there is a good establishment of the pathologic outcome of Chlamydia, the mechanisms of Chlamydia-stimulated tissues damage has not been fully identified. Traditional examination of the samples of tissue from women…show more content… Numerous mediators of inflammation are present during the process of infection, comprising interleukin-1β (IL-1β) as well as tumor necrosis factor-α (TNF-α). Mucosal cells tissues infected by Chlamydia include the dendritic cells, the epithelial cells, fibroblast, as well as the macrophages. Toll-like receptors are expressed by these cells that identify the particular pathogen-connected molecular patterns, comprising, bacterial wall mechanisms, the bacterial DNA, the peptidoglycan, as well as double-stranded RNA. It is noted that the Toll-like receptors’ engagement by the products of microbial, result to the production of the biologically-dynamic mediators, comprising the chemokines and antimicrobial peptides that participate in the inflammatory reaction (Barber, 2013).
Chlamydiae have many cell walls as well as components of the outer membrane that are recognized by the Toll-like receptors. It is vital to note that the Toll-like receptors, as well as the chlamydial heat shock proteins, have been found to be the primary ligands for both Toll-like 1 and Toll-like 2 receptors. Though the interaction of Chlamydia with the Toll-like receptors plays a key role regarding the start of the pro-inflammatory cytokine as well as the production of the chemokine, the cell lysis mode at the end of the infectious phase is expected to have a great outcome on the response of the host (Herieka, 2005).
There have been numerous studies on the epithelial cells as a