Chromatin Influences

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2 metres of DNA is packaged and folded by multiple mechanisms and occupy certain positions to form chromosomes in mammalian cells. Levels of folding and their positioning generate contacts between different regions of the genome. Such contacts are the result of distance between DNA sequences, their folding architecture and the proteins that are associated with them, directly or indirectly.
As cells differentiate into specialized cell types they undergo re-organization and many structural changes which affects gene expression patterns and cell functions. Chromatin interactions have important roles in gene regulation.
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