Chronic Myeloproliferative Disorder ( Mpd ) Is Associated With Mass Quantity Of Platelets That Are Put Out

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Essential thrombocythemia TERMINOLOGY CLINICAL CLARIFICATION This chronic myeloproliferative disorder (MPD) is associated with mass quantity of platelets that are put out by megakaryocytes Also known as Primary thrombocythemia Idiopathic thrombocythemia Has a prevalence 30/100000 in the general population11 CLASSIFICATION Not applicable DIAGNOSIS CLINICAL PRESENTATION History Half of all patients with essential thrombocythemia report no symptoms1 The rest of patient report symptoms either related to small or large vessel thrombosis or both Microvascular occlusion (small vessel): distal peripheral involvement like finger and toes Aspirin-sensitive erythromelalgia9 Patient might report digital pain that is made worst with exposure to heat and improves with cold and usage of aspirin Patient report 's neurologic involvements like: episodic transient ischemic attacks, paresthesias, vertigo, syncope, dysphoria, seizures, but most often headaches is the most common neurological complain Macrovascular occlusion (large vessel): may involve thrombosis of large veins and arteries the can occlude entire extremities or vital organs like heart (myocardial infarction), kidney (renal failure), brain (stroke), lung (pulmonary vascular occlusions), hepatic (Budd Chiari Syndrome) or priapism (rare complication) Bleeding is associated with essential thrombocythemia Bleeding could be internal or external related Internal: post-head trauma intracranial hemorrhage, hemarthrosis External:

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