Chronic Obstructive Pulmonary Disease

1269 Words Mar 9th, 2015 6 Pages
Chronic Obstructive Pulmonary Disease

The critical appraisal of a research article is a method of examining its validity, value and relevance to study. This assignment will focus on critically appraising a research article which evaluated the safety and efficacy of a drug (Glycopyrronium) used for chronic obstructive pulmonary disease, against a second drug (Tiotropium) used in the treatment of the same condition.

Chronic obstructive pulmonary disease (COPD) is the name used for diseases related to the lungs, which cause breathing difficulties due to the narrowing of airways in the lung. Patients suffering from COPD experience symptoms of breathlessness when enduring physical activity, a persistent cough with phlegm and recurrent chest infections. The main cause of COPD is smoking. The condition progresses slowly and is non-reversible, however pharmaceutical treatment is used to relieve the symptoms associated with the condition and to stall its progression.

Glycopyrronium is a used in the treatment of COPD. Its indication is for the maintenance treatment of chronic obstructive pulmonary disease (BNF 2014).
Glycopyrronium is a long-acting muscarinic antagonist. It helps to relax air passages and keeps the airways open in the lung allowing easier breathing. The drug is formulated as an inhalation powder.

Clinical evidence

My search for literature on the topic of Glycopyrronium was conducted using the university e-resources. I used a…
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