Chronic Pancreatitis Case Study

Acute Pancreatitis: Acute inflammation of the pancreas.The most common pathogenic mechanism is autodigestion of the pancreas. The etiological factor injures pancreatic cells or activates the pancreatic enzymes in the pancreas rather than in the intestine which may be due to reflux of bile acids into the pancreatic duct through an open or distended sphincter of Oddi. The result may also be caused by blockage created by a gallstone. Obstruction of pancreatic ducts results in pancreatic ischemia.The pathophysiology involvement of acute pancreatitis is

“Each year, acute pancreatitis sends more than 200,000 Americans to the hospital. Many of those who suffer from pancreatic problems are also heavy drinkers” (“Beyond Hangovers: Understanding Alcohol's Impact Your Health” 15). The pancreas is an important organ which aids in digestions and energy conversion. The pancreas directs enzymes to the small intestine to digest nutrients and it also secretes insulin and glucagon. The body’s main source of energy is glucose and insulin allows additional glucose to be stored away in the body properly. Too much alcohol damages cells in the pancreas, causing complications with insulin, leaving the organ open to inflammation. Alcohol causes the pancreas to discharge the enzymes intended for the small intestine back into the pancreas which can lead to inflammation and the swelling of tissues and blood vessels. Pancreatitis is the inflammation which causes the organ to malfunction and if one continues to drink, it can magnify into chronic pancreatitis when the inflammation is constant (“Beyond Hangovers: Understanding Alcohol's Impact Your Health” 15-16). Pancreatitis causing severe abdominal pain, persistent diarrhea, and is not curable. Sixty-percent of circumstances result from alcohol; although, some have been linked to gallstones (Freeman).

Inadequate nutrition secondary to alcohol consumption is not uncommon as the disease progresses (Merck, 2009).

Pancreatic Cancer is cancer of an organ in the human body called the pancreas, which is located behind the lower part of the stomach. The function of this organ is to secrete certain essential enzymes to digest food and also secrete hormones to metabolize sugars such as insulin and glucagon (Mayoclinic). People get pancreatic cancer when the cells of the pancreas develop genetic mutations; and these can form in both the exocrine and endocrine cells of the pancreas, but exocrine tumors are more common than endocrine tumors. Because this cancer spreads very quickly throughout the body and the symptoms of the disease don’t usually appear until the cancer is at an advanced stage, it is a leading cause of death

Over 2.5million people die every year to excessive alcohol use. Furthermore, alcohol is responsible for one in ten deaths of working age adults aged twenty to sixty four. Excessive drinking by the CDC is more than one glass a day for a woman and more than two glasses a day for a man. Also, drinking any while under the age or pregnant is classified as excessive drinking(“Alcohol Use and Your Health”). On top of the benefits becoming negative effects quickly, excessive drinking also comes with many more side effects. Excessive drinking damages the brain, heart, liver, pancreas, and the immune system. Brain cells are lost along with loss of thinking and coordination. Heart beat, heart muscles, and blood pressure can be effected. A variety of liver problems and inflammations. The Pancreas produces unwanted toxins eventually leading to pancreatitis. Lastly the immune system is weakened, making the body a much easier target for disease and slowing the body’s ability to ward off infections – even up to 24 hours after getting drunk(“Alcohol's Effects on the

The disease can also result in various obstructions of the pancreas, hindering digestion (World Health Organization, 2012, p.5).

The doctor may also take a blood test to determine if the jaundice is due to pancreatic cancer or liver disease. (Panno) Once the patient is diagnosed with pancreatic cancer, they can choose from different treatment plans. When determining the person’s treatment plan, they take consider their age and expected lifespan, other serious health conditions, the stage of the cancer, if surgery can remove cancer, likelihood of curing the cancer, and how the person feels about side effects. For many patients, the part that most important is the controlling of pain. Some treatments for the cancer include surgery, radiation therapy, chemotherapy and other drugs. (Treating) Treating pancreatic cancer is very difficult due to the dense outer shell around the pancreatic tumor and nearly impossible to penetrate with cancer-killing drugs. “Wall is so tough that clinical trials with medications that are experimental designed to breach barrier had to be abandoned mainstream, drug so harsh they sicken already ailing patients,” said Doctor Abram Handly-Santana, a researcher who specializes in pancreatic cancer. (Ricks) Even though treating pancreatic cancer is difficult, some doctor decide to perform surgery to determine if the tumor is removeable and to determine the staging of the cancer to prescribe the best treatment. (Panno) The best

Prenatal exposure to alcohol can cause profound amounts of birth defects and mental retardation. Drinking alcohol is composed of ethanol, a flammable liquid, which is made by fermentation. According to the National Institute on Alcohol Abuse and Alcoholism, alcohol can affect different parts of the human body such as the brain, heart, liver, pancreas, the immune system, and plays a role in cancer (NIH, n.d.). In the brain, alcohol can intervene in communication pathways, which affects how the brain works. Alcohol can cause many different heart defects and disorders such as cardiomyopathy, irregular heartbeats, stroke, high blood pressure and in some cases heart attack. Alcohol proves to be very damaging to the liver, especially in alcoholism. In many cases, the liver turns into scar tissue causing fibrosis and cirrhosis. Other liver problems can include having a fatty liver and alcoholic hepatitis. Alcohol-induced fatty liver disease, the first stage of alcohol-induced liver disease, occurs when fat is depositing in liver cells. Alcoholic hepatitis is very similar to fatty liver disease, although it presents with inflammation and scarring of the liver. Many alcoholic’s liver becomes so scarred that it is irreversible, which is called alcoholic cirrhosis. Alcoholic cirrhosis is the most progressive form of alcohol-related liver disease and presents as severe scarring, with termination of normal liver structure. The pancreas is also affected by long-term

Acute pancreatitis is an acute inflammatory process ranging from mild abdominal discomfort to severe disease involving multiple organ systems. Diagnosis is based on the presence of at least two of the following three features: abdominal pain; increased pancreatic amylase, and/or lipase levels to ≥3 times the upper limit of normal; and imaging tests showing characteristic findings of acute pancreatitis. The incidence of acute pancreatitis is known to differ geographically due to differences in alcohol consumption or in the incidence of gallstones disease in different parts of the world. Cholelithiasis is the leading cause of acute pancreatitis

As part of that process, the pancreas gives off these digestive enzymes that combine with waste from the gallbladder to help break down your food. Drinking too much alcohol can cause the pancreas to produce toxic substances that are very bad for your body and can interfere with proper functioning such as the breaking down your food. The resulting swelling of the pancreas is called pancreatitis, a very serious problem that can case the pancreas to be destroyed. One of the most common causes of chronic pancreatitis is linked to alcohol abuse.The liver’s job is to break down all the bad stuff you put in your body, including alcohol. Excessive drinking can cause alcoholic can lead to the development of jaundice (yellowing of the skin and eyes). Chronic liver inflammation can lead to severe scarring.. This buildup of scar tissue can totally destroy the liver. When the liver fails to perform, the really bad toxic stuff will remain in your body. Liver disease is extremely life threatening. Women are at a higher risk for getting alcoholic liver disease than men, because women’s bodies tend to absorb more alcohol and take longer to burn it off. When the pancreas and liver won't function properly, the risk of low blood sugar rises. A damaged pancreas can cause the body to be unable to use the sugar you put in your body due to a lack of insulin, which can lead to

Diseases like heart disease and diabetes can result from alcohol abuse. The increase of hospital visit due to alcohol consumption have increased in the adult population. Alcohol abuse is a problem in all ages and

Mitochondrial damage is therefore a serious threat to the viability of the acinar and ductal cells, as well as the pancreas as a whole. Bile acids and ethanol metabolites, among the most common pancreatitis-inducing factors, act by causing the release of stored Ca2+ within the ER and inducing extracellular Ca2+ influx. This prolonged increase in cytosolic Ca2+ concentration leads to mitochondrial Ca2+ overload and decreased intracellular ATP levels. SERCA and PMCA pumps, which remove Ca2+ from the cytoplasm, require ATP to function and will become less active; further contributing to the sustained elevation of cytosolic Ca2+ concentration. This continuous overload causes mitochondrial membrane permeabilization and overall damage to the mitochondria.

Alcohol causes many psychological and physiological problems in heavy drinkers and light drinkers alike. A few well-known consequences of alcohol on the brain and body have been proven. This includes: cognitive mood and memory disturbances, injury to the gastrointestinal and intestinal tracts, and injury to cardiovascular, all of the body’s normal functions. Fetal alcohol syndrome is a growing problem. Fetal alcohol syndrome occurs when expectant mothers drink during pregnancy. This condition afflicts over 5,000 infants a year causing mental retardation, constant confusion, withdrawal after delivery, and many visible physical defects. Cirrhosis of the liver is the most common alcohol related health problem. Approximately 10,000 to 24,000

Excessive alcohol use can cause the pancreas to produce toxic substances that interfere with proper functioning. The resulting inflammation is called pancreatitis, a serious problem that can destroy the pancreas. One of the most frequent causes of chronic pancreatitis is alcohol abuse.

Ingestion of more than 50 –70 g/day of alcohol for prolonged periods is defined as heavy alcohol intake, which is a well- known HCC risk factor. The link between the amount of alcohol intake and the risk of HCC is still unclear. Although heavy intake is associated strongly with the development of cirrhosis, there is little evidence of a direct carcinogenic effect of alcohol otherwise. But it was found that there is a synergistic effect of heavy alcohol ingestion with HCV or HBV which are operating together to increase HCC risk by more actively promoting cirrhosis. In a study it was reported that HCC risk increased in a linear fashion with daily intake of more than 60 g. But with the concomitant presence of HCV infection, there was a 2-fold