Cigarette Self Observation

Satisfactory Essays
Cigarette smoke induces oxidative stress, which may lead to lung injury and emphysema development. We found high mitochondrial DNA damage in alveolar type II cells isolated from individuals with this disease. We have discovered that XLF is involved in repair of mitochondrial DNA in these cells. XLF oxidation causes its degradation leading to mitochondrial dysfunction and mitophagy in these cells. Targeting XLF may provide potential therapeutic strategy against emphysema
Get Access