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Circadian Rhythms And Metabolic Health Essay

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1. This paper is concerned about circadian rhythms and metabolic health, which can be affected by the timing of food intake. Also, the paper is concerned about the affect it has on mice when consuming a large meal before breakfast, and smaller meal for dinner compared to mice who only consumed breakfast. This paper suggests that during inactive period, the consumption of high-fat foods results in weight gain. What they are now concerned about is the timing, and size of the meal being consumed to show if this has an effect on mice.
2. The researchers are trying to figure out if mice that consumed one meal a day (breakfast only), and mice that consumed two meals a day (larger breakfast, smaller dinner) have an effect on obesity, lipid metabolism, and circadian clock gene expression. They are also trying to find out if the timing of these meals has an affect on metabolism, and weight gain. Researchers are trying to find out which diet plan will help mice maintain a normal weight and prevent a surplus amount of adipose tissue accumulation.
3. They conducted this experiment in a lab in Tokyo, Japan with six-week-old ICR mice that were held at a temperature of 22.2 °C, humidity of 60.5%, and under 12h light/12h dark. The researchers conducted experiments which used high-fat diet as free-feeding condition. Because insulin and leptin levels are increased, and adiponectin levels are decreased they measured the levels of serum, leptin, and adiponectin to test for metabolic syndrome.

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