Clinical Distinction Between Acute Bacterial Meningitis ( Abm ) And Viral Meningitis

1405 Words Sep 17th, 2016 6 Pages
Accuracy of Heparin Binding Protein; a new marker; in prediction of Acute Bacterial Meningitis
M. H. Kandil1, G. I. Khalil1, E. A. El-Attar1, G. M .Shehata1, S. Hassan2
1Medical Research Institute, Alexandria University, Alexandria, Egypt, 2Ministry of Health, Alexandria, Egypt
Abstract: Background: The clinical distinction between acute bacterial meningitis (ABM) & viral meningitis is difficult in the acute phase of illness. Bacterial culture of Cerebrospinal fluid (CSF) is the gold-standard technique for confirmation but approx. 50% of cases are not confirmed. Antibiotics are often instituted before lumbar puncture, reducing the chance of a microbiological diagnosis. Objective: to evaluate the role & efficacy of CSF & serum Heparin-binding protein (HBP) in diagnosis of bacterial meningitis. Patients: 30 patients diagnosed with ABM, 30 diagnosed with patients with viral meningitis & 30 subjects with normal CSF examination findings (controls). Setting: Ministry of Health specialized hospital, Alexandria, Egypt Design & Measurements: Diagnosis was based on history, clinical criteria, CSF examination, latex agglutination & culture and sensitivities. HBP was measured using in both serum & CSF. Intervention: none. Results: CSF HBP levels averaged 0.82 ± 0.3 ng/mL in controls, 3.3 ± 1.7 ng/mL in viral meningitis & 174.8 ± 46.7 ng/mL in ABM. The mean serum HBP level was in the controls 0.84± 0.3 ng/mL in controls, 3.7 ± 1.9 ng/mL in viral meningitis & 192.2 ± 56.6 ng/mL in ABM.…

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