Clozapine Research Paper

I would recommend atypical antipsychotic drugs such as clozapine because they “appear to be more effective than conventional drugs” (Comer, 2015).

Researchers believe that dopamine plays an important part in schizophrenia. The goal of conventional antipsychotic drug therapy is to reduce the amount of dopamine, or the amount of dopamine receptor sites. They are dopamine antagonists

Antipsychotics (also known as neuroleptics or major tranquilizers) are a class of psychiatric medication primarily use to manage psychosis (including delusions, hallucinations, or disordered thought), in particular in schizophrenia and bipolar disorder, and are increasingly being used in the management of non-psychotic disorders.

It is also used to treat normal sleeping patterns and appetite, and for reducing anxiety. It works by modifying the activity of relevant neurotransmitter pathways.Some of the categories of antidepressants, defined in (Queensland state Government, 2018) are :

Antipsychotics are medications that physicians use to treat psychotic disorders such as Schizophrenia, Delusional disorder, Paraphrenia, and Substance-induced psychotic disorders. These disorders are characterised by the patient’s inability to make good judgments, think with a clear head, communicate effectively, relate to society, and understand reality. Antipsychotic drugs are also useful in the treatment of bipolar conditions that involve extreme cases of manic behaviour. Examples of these drugs include Thorazine and Trilafon. These drugs belong to a drug class called phenothiazines. They work by changing the actions of chemicals in the brain. The drugs can be beneficial, however, Steen et al. (2014) argue that the medicines have several harmful effects such as changes

There are so many different kinds of medications used to treat patients, but the most common ones that psychiatric assistants prescribe exist as antipsychotic and antidepressants. Antidepressants usually relate to a substance that treats mood disorders. Antipsychotic medications usually are taken daily in pills or liquid form. However, some may get injected, which means their only given once or twice a month. The biggest mental disorder that antipsychotic are prescribed for has occurred in patients with schizophrenia. “Schizophrenia is a psychosis characterized by delusions, hallucinations, apathy, and a “split” between thought and emotion.” (Coon & Mitterer 487) “Patients with this disorder tend to have withdrawal from contact with other, a loss of interest in external activities, a breakdown of personal habits, and an inability to deal with daily events.” (486) “Also, it is hard for patients with schizophrenia to focus on one item of information at a time.” (486) Four major types of schizophrenia consist of catatonic, disorganized, paranoid, and undifferentiated. The first type, catatonic, involves disturbances in a person’s movement. Patients with this disorder type tend to just sit there and they do not talk or move. They show no emotion. “The second type, disorganized, or known as “hebephrenic schizophrenia”, patients experience bizarre thinking and flat or grossly inappropriate emotions.” (487) “Typically, this type of schizophrenia develops in adolescence or young adulthood.” (487) “The third type, paranoid, is marked by a preoccupation with delusions or by frequent auditory hallucinations related to a single theme, especially grandeur or persecution.” (488) “Patients think that God, the government, or “cosmic rays from space” are controlling their minds or trying to poison them.” (488) “According to the largest study ever

In 1955, antipsychotic medications were introduced to help mental disorders. These medications are usually taken orally in which help relieve symptoms for periods of days. The misuse or abuse of the medications are low. There are three generations of antipsychotic medications. The first generation is known for reducing hallucinations and delusions, but not affecting problems like disorientation or depression. An example would be chlorpromazine, brand name being Thorazine. Some negative side effects of taking the first generation drugs are Parkinson’s-like symptoms, tardive dyskinesia, and weight gain. Next, the second generation drugs minimized the outcome of the individual getting Parkinson’s-like symptoms. An example of this generation would be Clozaril. “A unique feature of Clozaril is the 1 to 2 percent chance of developing a potentially lethal blood disease called agranulocytosis” (Levinthal 282). This disease decreases white blood cells and affects the immune system. If early signs of this disease start to appear the patient will stop taking Clozaril and recover. Lastly, the third generation has shown to be the most effective on schizophrenia. Abilify is an example of this generation drug. It does not have a risk of Parkinson’s, tardive dyskinesia, or diabetes. Abilify blocks specific serotonin receptors in which prevents negative side effects from happening. These different

Antipsychotics are generally used to treat psychosis in mental disorders. These disorders include schizophrenia and bipolar disorder (Thyssen et al., 2010). Risperidone is known as an atypical second generation antipsychotic and used in the treatment of a multitude of disorders. This medication can often challenge behavioral problems that are associated with schizophrenia, autism spectrum disorder, bipolar disorder, or attention deficit hyperactivity disorder (Schatzberg & Nemeroff, 2013). It is important for the prescriber to be aware of the side effect and any possible adverse reactions that may occur. There can be many detrimental side effects that someone may not enjoy,

Because of the prevalence of copious quantities of dopamine in people who have schizophrenia, most medications attempt to prevent the buildup of dopamine by blocking it in the striatum. Other methods in which drugs for this condition help to counteract the effects of dopamine, however, are more indirect. There are medications that are under development that "interfere with glutamate signals in the brain" (Nauert, 2010) that are targeted towards affecting glutamate, which in turn will then positively influence the levels of dopamine that the brain releases. In both ways then, (direct and indirect), dopamine is the primary focus of schizophrenia medication.

Treatment will often include antipsychotics for the illness itself, anticholinergic drugs to help treat extrapyramidal symptoms (movement disorders), that are caused by antipsychotics, and in some cases cognitive remediation. Cognitive remediation techniques are time and labor intensive, because cognitive deficits are multiple and vary from person to person. Such techniques seem to work best when specifically tailored to each patient. ("Schizophrenia Treatment & Management: Approach Considerations, Antipsychotic Pharmacotherapy, Other Pharmacotherapy," 2018). When combined with drug therapies, cognitive remediation is successful. Drugs included in therapy are Risperidone, Clozapine, and Olanzapine, which produce their effects with reduced incidence of extrapyramidal symptoms. Clozapine has the adverse effect of dangerously depressing bone marrow function and the patient must have their blood count checked on a biweekly basis, if white blood cells drop too low, it is discontinued. (Timby & Smith, 2014) Other antipsychotics include Haloperidol, Fluphenazine, Risperidone, and Olanazapine, all of which block dopamine receptors. Common anticholinergic drugs are trihexyphenidyl and benztropine. These drugs should all be taken as prescribed and should never be stopped abruptly due to withdrawal symptoms or more severe adverse

In 1995, Depakote was approved by the FDA for the treatment of bipolar disorder and is slowing becoming the most widely prescribed drug for the use on mania. Depakote hasn't totally replaced lithium; however, it is being used on patients that were not previously treatable with lithium. Compared with lithium, Depakote doesn't have all the bad side effects when properly administered. Patients taking Depakote find their thinking is clearer and don't seems to have the kidney and thyroid problems (Burns 104-106). The antipsychotic drug Clozaril also has been used to stabilize the moods of bipolar disorders, especially those that have not responded to lithium and the anticonvulsants. One major side effect of Clozaril is that is suppresses the production of white blood cells on about 1% of patients (Harvard Mental Health Letter, June 1997). Because of this side effect, doctors have to be extremely careful when prescribing.

Zoloft is a “selective-serotonin reuptake inhibitor commonly prescribed as an antidepressant. Zoloft affects chemicals in the brain that may become unbalanced and cause depression, panic, anxiety, or obsessive-compulsive disorders. It is used to treat depression, post-traumatic stress disorder and premenstrual dysphoric disorder”. (Cerner) “Depressive symptoms are the result of a biochemical imbalance in the brain, a disturbance in the brain’s chemical messengers called neurotransmitters. Zoloft acts on the neurotransmitter serotonin, allowing electrical messages to be processed more smoothly and efficiently. This helps relieve symptoms of depression. Zyprexa is an antipsychotic medication. Zyprexa works to reduce symptoms of schizophrenia by blocking various serotonin and dopamine receptors. It blocks the serotonin receptors more potently than dopamine. Ativan is a sedative medication generally used to treat anxiety. Ativan works by increasing the activity of a neurotransmitter called gamma-aminobutyric acid which inhibits the nervous system, reducing the states of mental and physical overexcitement”.

The medication that Mrs. A is on is Clozapine. The decision to use clozapine is not taken lightly because of the potentially life threatening side effect. An awareness of side effects is important to primary care practitioners because they have most contact with the patients.

Antipsychotics are classified as major tranquilizers that are used to treat mental health illnesses such as schizophrenia, bipolar disorder, and other mental illnesses. They can also treat severe depression and severe anxiety. These antipsychotics drugs reduce or increase the effect of neurotransmitters in the brain to regulate levels that help transfer information throughout the brain. The neurotransmitters that are affected are the serotonin, dopamine, and noradrenaline.

Quetiapine is an atypical antipsychotic drug (APD) for the treatment of symptoms in patients with schizophrenia. This drug effectively alleviates positive and negative symptoms as well as cognitive impairment [1–3]. In addition, quetiapine is well tolerated and causes the lowest incidence of extra-pyramidal symptoms [1,4]. Moreover, quetiapine ameliorates psychotic symptoms in patients with Alzheimer’s disease (AD) and Parkinson’s disease (PD), and improves cognitive function in patients with these neurodegenerative diseases [5–8]. The therapeutic effects