Introduction
Hemophilia is a rare genetic blood clotting disorder that primarily affects males. People living with hemophilia do not have enough of, or are missing, one of the blood clotting proteins naturally found in blood. Two of the most common forms of hemophilia are A and B. In persons with hemophilia A (also called classic hemophilia), clotting factor VIII is not present in sufficient amounts or is absent. In persons with hemophilia B (also called Christmas disease), clotting factor IX is not present in sufficient amounts or is absent. People with hemophilia do not bleed more profusely or bleed faster than normal; they bleed for a longer period of time.
Virtually all people who have hemophilia A or B are born with it. The
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Because blood does not clot
when it should, patients experience frequent and excessive bleeding. The degree to
which bleeding occurs depends in part on the severity of the disorder. Patients can
have severe, moderate or mild hemophilia.
A hallmark of severe hemophilia is spontaneous bleeding. In these cases, bleeding
occurs without any recognizable trauma. Bleeding can occur in any part of the body.
However, spontaneous bleeds are unusual in the joints of the fingers, wrists, feet and
spine. Spontaneous bleeds are most common in the knees, ankles, elbows and
shoulders. Repeated bleeding into the joints is called hemarthrosis.
Hemarthrosis usually begins after the child begins to walk. As the bleeding begins, the
person may experience a warmth or tingling in the joint. As bleeding progresses, there
is usually a feeling of stiffness, fullness, and pain. The joint swells and may be warm
and tender. Bleeding into the joint limits the ability to move the joint. If not treated,
hemarthrosis can cause chronic joint problems.
Severe hemophilia can cause bleeding from circumcision. Bruising often occurs after
injections in infants. As the child becomes more active, excessive bruising occurs.
Excessive bleeding also occurs when teeth are pulled or other trauma occurs.
Symptoms of moderate hemophilia are the same as those for severe hemophilia with
one exception. Spontaneous bleeding is rare in moderate hemophilia. When
some stiffness these symptoms my stay the same or progress or get worse within time. Arthritis
Hemophilia is an X-linked recessive disease in which blood lacks blood-clotting proteins. Females have two X chromosomes, indicating that they are generally carriers and transmit the gene to their sons. People with mild hemophilia bleed after surgery, injury, or trauma. Severe hemophilia produces spontaneous internal bleeding in joints and muscles. Fortunately, medicines and lifestyle changes offers hemophiliacs fairly normal lives. Through learning about hemophilia, I became interested in genetic diseases and finding a cure for those
Also, your joints will be visibly swollen, especially in the morning. The pain and the swelling will be initially mild and they will increase gradually.
Often presents with unilateral leg swelling, redness, or pain in the calf or thigh 2
• Stiffness and pain in the joints. Usually, the joints in the hands, wrists, and ankles are the ones affected. This symptom may also last for weeks, especially in adults.
A doctor will examine for any tenderness, swelling and redness. Most likely a doctor will request x-rays and magnetic resonance imaging (MRI). There are also other ways to confirm a diagnosis by requesting to have the person get blood work done or having a joint fluid analysis.
This causes a result of pain, stiffness, swelling, and a difficult ability to move. Women are more likely
OA pain, swelling or stiffness may make it difficult to perform ordinary tasks at work or at home. Simple
- Pain areas: In the knee -Muscular: Abnormality walking or muscle weakness. -Also Common: Stiffness ❏
Hemophilia is a genetic bleeding disorder that slows down the clotting process of one’s blood. There are two types of the disorder: hemophilia A and hemophilia B. Both result in very similar symptoms, however, they are caused by different mutations of genes on the X chromosome. The way in which the disorder is inherited is known as an “X-linked recessive pattern.” Since males only have one X chromosome, one gene mutation is all that is needed in order to obtain hemophilia. On the other hand, females have two X chromosomes meaning that two mutations (on on each X chromosome) are required to inherit hemophilia. For that reason, it’s far more unlikely for females to have hemophilia than it is for males. Specifically, the genes which cause
Prevalent arthritis joint signs involve inflammation, discomfort, stiffness and lessened choice of motion. Indicators may appear and
If you have Bursitis, the affected joint may feel achy or stiff, it will hurt more when you move it or press on it, and it may also look red or swollen. “Your doctor will diagnose bursitis with a physical exam and tests such as x-rays and MRIs. He or she may also take fluid from the swollen area to be sure the problem isn't an infection.” (MedlinePlus, 2016)
Hemophilia is the oldest known hereditary bleeding disorder. There are two types of hemophilia, A and B (Christmas Disease). Low levels or complete absence of a blood protein essential for clotting causes both. Patients with hemophilia A lack the blood clotting protein, factor VIII, and those with hemophilia B lack factor IX. A person with severe hemophilia has less than 1% of the normal amount of a clotting factor - either Factor VIII (8) or Factor IX (9). People without hemophilia have between 50-150% of the normal level of factor VIII or IX. There are about 20,000 hemophilia patients in the United States. Each year, about 400 babies are born with this disorder. Approximately 85% have hemophilia A and the remainder has hemophilia B.
The most common symptom of arthritis is joint pain. However, joint pain may result from other illnesses, and this means that people experiencing joint pain have to consult a medical professional for differential diagnosis. Joint stiffness and swelling are also common in people with the disease. The most common symptom reported is a constant pain that occurs around a given joint. Moreover, other types of arthritis such as osteoarthritis and rheumatoid arthritis that can also affect other body organs and cause other symptoms
Hemophilia is a problem with the blood in a person that causes them to bleed not any faster than normal, but they often bleed for a longer period. Their blood is missing the clotting factor (a protein in the bloodstream that works to control bleeding). Hemophilia is quite rare; roughly 1 in every 10,000 persons are born with it. Rarely, hemophilia can be an acquired disease which just means a person is not born with it, but will develop it during their lifetime. This rarity occurs when a person's immune system forms antibodies that attack the clotting factor in the blood. The entire antibody population fights against the blood to prevent the clotting factors from working properly.