Cocaine: A Powerfully Addictive Stimulant Drug

Cocaine, a narcotic drug that took the entire world by storm in the 1980’s, has continued to find it’s way into countries all over the world. The drug is a highly addictive stimulant that is extracted from the leaves of the Erythroxylon coca bush, which is indigenous to the Andean highlands of South America. It comes in two main forms, powder and crystalline, also known as “crack” (“Cocaine Use and Its Effects”). Although the short term effects of cocaine seem somewhat harmless, the long term effects are devastating and have ruined the lives of many users. The short and long term effects of cocaine can be seen on Ishmael Beah, and his companions in the novel A Long Way Gone by Ishmael Beah.

Cocaine is one of the oldest, most powerful and most dangerous stimulants in the world. This powerfully addictive drug effects over 35 million people In the United States. Cocaine addiction prevents a person from being a productive member in our society. It also increases the cost for law enforcement and treatment facilities. It rapidly decreases the workplace, increases the homeless rate and needless deaths on a daily basis.

"Cocaine and crack are among the most addictive substances known to modern science, and they have already ruined the lives of millions of Americans" (Morganthau and Miller, 208). Cocaine and crack are both dangerous, harmful drugs. Though pleasurable effects can be obtained from these drugs, the use of crack and cocaine cannot be worth the actual consequences that are inflicted on mind and body. The bad effects of these drugs, by far outweigh the good. Because crack and cocaine are so closely related, it is important to have a firm understanding of both drugs.

Crack cocaine has been popular since the 1970s and mid 1980s. Crack cocaine is not a new drug; this drug is obtained from coca plant which grows mainly in South America. For many years, the native South American Indians chewed its leaves to develop strength and increased energy. By the 1800s, the cocaine was secluded from its leaves and used as a medicinal drug. By the late 1800s, it was used as an anesthetic and to avert surgical hemorrhage. The next century, people recognized crack cocaine an addictive narcotic and its non-medical use of the drug was ended by the Harrison Narcotics Act in 1914 (“How crack cocaine works?”).

It wasn’t until the mid-1800s that a PhD student in Germany created an isolated cocaine alkaloid that would be used as the first anesthetic. Albert Niemann, the student who perfected cocaine purification process, noted many properties of drug. One journal esteemed its bitter taste and temporary numbness the pharmaceutical caused. By the late 1800s, the drug’s known applications became increasingly popular. Cocaine became the go-to cure for everything from epidurals to tooth aches. When combined with alcohol, the resulting cocaethylene generated a potent concoction with potent effects, making cocaine

Cocaine originated from South America, from coca leaves. Originally, the coca leaves were chewed by workers to decrease fatigue, improve endurance and have a greater resistance to the cold. This was to benefit the workers so they could work longer hours and be more productive. In 1855 the active ingredient in cocaine was isolated from the leaves, and in 1880 it was used as a local anesthetic (Nunes,2006). It was also used in coca cola. In 1855, coca cola was a soda beverage that contained sixty milligrams of cocaine for every eight ounces of the beverage. The idea behind this was to give people energy and a sense of well being (Nunes, 2006). By the late 1880s Sigmund Freud was using cocaine regularly and was even recommending it to others.

For short-term use, cocaine can provide extreme happiness, enhanced sensitivity to sound and touch or mental alertness. People takes cocaine as it can provide energy on their work but a long-term use of cocaine may lead to malnourishment, irritability, restlessness, paranoia and auditory hallucination (NIDA, 2016; Roncero, C., et al., 2013). Also, cocaine abuse may have other complications such as nosebleed because of snorting, difficulties in swallowing and easily infected by HIV or hepatitis C through needle injection and the misjudgment on having unsafe sex (NIDA, 2016). On the other hand, long-term use of cocaine may lead to addiction and a stronger dosage will be taken when they have any withdrawal symptoms. For instance, symptoms of depression, fatigue and increased appetite. Nowadays, still no medicines were approved for treating the addiction on cocaine and thus the treatment of cocaine addiction is

One of the most detrimental and addictive narcotics in the world today is cocaine. Cocaine dates back as early as 3000 BC. Ancient Incas used the coca leaves to counter the effects of living in thin mountain air. Native Peruvians in the 1500’s chewed the plant strictly for religious ceremonies. Andean Indians are believed to chew the leaves of the coca plant to increase their energy for work while decreasing their hunger and pain. It wasn’t until 1859 when a German chemist Albert Niemann successfully extracted the narcotic from the coca leaf. In the 1880’s, it was freely prescribed by physicians for “maladies as exhaustion, depression, and morphine addiction and was available in many patent medicines” (“Cocaine”), until users and doctors began to realize its dangers and side effects. While it was not fully understood at the time, cocaine has many devastating and lasting effects on the user.

Cocaine’s mode of action has been shown to involve the dopamine receptors. This paper will discuss how cocaine affects dopamine receptors, the mode of addiction, how cocaine affects the frontal brain metabolic activities, as well as the role of excitatory amino acids in cocaine’s mechanism. I will also discuss how cocaine affects another system through its mechanism on the brain—the renin angiotensin system.

Cocaine’s primary effect on the brain is to produce “psychoactive and addictive effects primarily by acting on the brain’s limbic system, a set of interconnected regions that regulate pleasure and motivation. Initial, short- term effect- a buildup of the neurochemical, dopamine which gives rise to euphoria and a desire to take the drug again”(Nestler, 2005, p.4). This is normally seen in some individuals that draw in the drug like through inhaling. It gives them an instant increase in blood, and brain levels. It causes the individual to become addicted to this substance. Cocaine is thought to produce pleasure/reward like any addicted drug

often to beat, using cocaine can make the heart pump so fast that it damages the

Cocaine Hydrochloride in the early 20th century was used in many ways. Some may say that small doses were added to the drink Coca Cola, that’s where the name come from. I feel as if this is true because Coca Cola is slightly addictive. The original formula of coca cola did have 25mg of cocaine per 100ml of drink. That formula was used as a stimulant for headaches. Cocaine Hydrochloride was an ingredient in patent medicines, tonics, elixirs, and fluid extracts. With the right amount it could save and cure you but if you were given more than needed you would get addicted. Doctors knew what would happen to a patient if they were given to much therefore they created something called the Harrison Narcotic Act of 1914.

It is composed of many functional groups, which explain for the different types of functions. Cocaine has an educational background both in science and in history. It has been used recreationally throughout history and made its way to the European continent and other areas after the European colonized in South America. The native people of South America used to chew on coca leaves to extract the compound and use it as a source for energy and power to complete daily tasks. There is also evidence of the natives using this coca leave for medicine. The medicine component behind cocaine dates back to centuries ago. The skeletal remains show that some people used to chew on it as they were going through a medical procedure. These people had residue left in their cheekbones, and there was a hole in their skull. This signified that the people went through a medical procedure to get treatment for brain illnesses. The ones without these holes show that it was being used recreationally. It has a rich, detailed scientific background as many people sought to uncover the pure substance. Uncovering the pure substance only lead to further advancement in medicine; Cocaine was being used as a local anesthetic. People further went on to create derivatives of cocaine, which are the more popular anesthetics used in medicine right now. Some of these anesthetics include Benzocaine and Lidocaine. These anesthetics are typically used to treat ulcers. Cocaine, today, seems to be more of a social issue due to numerous people abusing the drug and getting addicted. It is evident that there are beneficial and detrimental uses of the drug. Cocaine can cause harm when it is abused or used in the wrong way. It can lead to serious complications and consequences. However, Cocaine also has great application in the medical field. It can be used as a good way and lead to many

The drug Cocaine alters chemical levels in the brain which can lead the user to have the ‘feel good’ factor.

Cocaine, on the other hand, has been found to have a profound effect on increased dopamine activity. Kennedy & Hanbauer (1983; cited in Karch, 2007) found a strong correlation between cocaine binding and the inhibition of dopamine uptake, and therefore proposed that dopamine transporters are binding sites for cocaine. Such research, which correlates strong reinforcing properties of cocaine with inhibition of dopamine transporters, suggests that cocaine has a more significant affect upon dopamine, than than it has upon serotonin and noradrenaline. The excessive role of dopamine can explain the high degree of pleasure that users of cocaine experience, as well as depression and cravings, which follow.