Coeliac Disease: Gastrointestinal T

When the gluten reaches the small intestine, it activates the immune system to attack the intestine lining. Destroying the finger like projections called Villi which are involved in the absorption of the nutrients.

Celiac disease is a fairly common disease but is not very well known. Celiac disease, or celiac sprue, is a digestive condition triggered by consumption of the protein gluten (Hill, Clinical manifestations and diagnosis of celiac disease in children, 2011). Gluten is a protein found in wheat, barley, rye, and oats. People with celiac disease who eat foods containing gluten experience an immune reaction in their small intestines, causing damage to the inner surface of the small intestine and an inability to absorb certain nutrients (Hill, Clinical manifestations and diagnosis of celiac disease in children, 2011).

Celiac disease is an inherited autoimmune digestive disorder that damages the hair-like structures (villi) on the lining of the small intestine. This hampers the absorption of nutrients into the bloodstream and leads to malnourishment. Celiac disease is the world’s most common genetic autoimmune disorder, affecting three million Americans, or about 1 in 141 people.

Coeliac disease is an autoimmune disease, meaning that the body’s immune system is responsible for the ill symptoms by attacking the body’s cells. This is different from an allergy, in that basophils and eosinophil are specifically responsible for allergic responses (Celiac Disease Foundation). When an individual with coeliac disease consumes wheat, barley, or rye [which contain the protein gluten]; it triggers the immune system to attack the body. The small intestine is usually a main target; specifically the villi, which are finger-like projections that line the small

Did you know that if you have celiac diease it can stun your growth? There's no cure for celiac disease — but following a strict gluten-free diet can help manage symptoms and promote intestinal healing. If you have celiac disease, eating gluten triggers an immune response in your small intestine. Over time, this reaction produces inflammation that damages the small intestine's lining and prevents absorption of some nutrients (malabsorption). When people with celiac disease eat gluten (a protein found in wheat, rye and barley), their body mounts an immune response that attacks the small intestine. These attacks lead to damage on the villi, small fingerlike projections that line the small intestine, that promote nutrient absorption. When the

"Name the organ, and celiac disease can affect it," says Dr. Peter Green, director of the Celiac Disease Center at Columbia University. In launching its assault on gluten, the immune system generates antibodies to an enzyme called tissue transglutaminase. This enzyme is an innocent bystander that acts on gluten in the lining of the intestine. But because the enzyme is also found throughout the body—in the skin, heart, thyroid, bones and nervous system—antibodies that attack it can direct their fire at any of these other organs, too.”

CD in the pediatric population complicates recognition of the disease in many patients. Treatment for CD consists of a lifelong strict gluten-free

which we cannot digest the proteins found in gluten Pancreatic enzymes such as lipase have been

     There are such a vast variety of symptoms in celiac that it can be very hard to diagnose. Symptoms may or may not be in the abdomen. One person can have diarrhea or abdominal pain while another has irritability and depression. Irritability is the most common symptom in children. Some symptoms of the disease are:

Celiac’s disease is a digestive and autoimmune disorder that happens when you eat foods that contain gluten. An autoimmune system happens when your body mistakenly attacks its own tissues, because it thinks it’s bad (http://www.news-medical.net/health/What-is-Autoimmune-Disease.aspx). So, your immune system reacts to the gluten, as it harms something called villi, which is in your small intestine (http://www.webmd.com/digestive-disorders/celiac-disease/celiac-disease). Villi are lined all around your intestine, and they are very important. They look like little, tiny hairs, and they absorb all of the nutrients you need! Because they get damaged, though, nutrients can’t be absorbed, and you may end up being malnourished, even if you eat a lot!

Celiac disease is a chronic autoimmune disease that is associated with genetic, environmental and immunological factors. The disease is closely associated with genes that code for human leukocyte antigens DQ2 and DQ8 haplotypes. In general, celiac disease has been recognized as a T lymphocyte associated disorders in which proteins derived gliadins, in the form of naive or deamidated by tissue Transglutaminase, activate T lymphocytes and as a result, release proinflammatory cytokines Such as IFNγ,IL-17,IL-21 and etc. these cytokines lead to histopathological changes like villous atrophy, Crypt hyperplasia and etc. In addition, celiac disease has a specific antibody against gluten and an autoantigen of the transglutaminase 2 that provides strong

Celiac Disease is a disease in which the small intestine is hypersensitive to gluten, leading to difficulty in digesting food. Celiac disease cannot be caught like a sickness. You can get celiac disease from a number is reason. The precise reasoning for developing this disease is not confirmed nor confined to a particular age range or gender, although more women are diagnosed than men.Celiac disease is now recognized as one of the most common chronic diseases in the world.

Coeliac disease is an autoimmune disorder affecting primarily the small intestine. It is a genetically inherited disease that is frequently diagnosed in adulthood in individuals, in whom the disease runs unidentified for years and can affect child growth. In cases of coeliac disease, the immune system reacts abnormally to gluten, which are various proteins found in wheat and in other grains such as barley, and rye. When gluten reaches the digestive tract and is exposed to the cells of the immune system, they mistakenly believe that it is coming from some sort of foreign invader, like a bacteria. In coeliac disease, the most severe form of gluten sensitivity, the immune system attacks the gluten proteins, but it also attacks an enzyme in the cells of the digestive tract called tissue transglutaminase. Consequently, gluten exposure in coeliacs causes the immune system to attack both the gluten as well as the intestinal wall itself. This

Celiac disease (also referred to as celiac sprue, non-tropical sprue, and gluten-sensitive enteropathy) is a chronic inflammatory disease of the gut mucosa in genetically susceptible individuals. The term ‘Celiac’ literally means pertaining to the abdominal cavity and is derived from the Greek word ‘hollow’. The disease is precipitated by the ingestion of gluten – a major storage protein derived from wheat (gliadin), barley (hordein), rye (secalin) and other related grains. When the grain is milled and mixed with water, it forms a viscoelastic network. This viscoelastic property is what makes wheat suitable for the preparation of a variety of food products. There are also hidden sources of gluten which include oats, sauces, drug fillers and

Gluten is usually referred to some group of proteins that are present in our everyday food items such as in wheat, barley, unprocessed oats, spelt, rye, semolina and any other form of flour. There are usually two main types of gluten proteins - glutenin and gliadin. Out of these, gliadin is the main culprit which offers harmful effects leading to obesity and many types of brain disorders. Although there is still debate going on about avoiding gluten from the food, it's always advised to have gluten free food as healthy snacks intermittently in order to have a balanced bowel activity and keep the energy flow running.