Coexistence of Autoimmune Disease with Type I Diabetes Mellitus in Libyan Patients

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MATERIAL AND METHODS The prospective clinical study was undertaken on 849 patients admitted in endocrine department of Tripoli Medical Center from December 2007 to July 2008. From the patients files, the concomitant disease presence or absence was also recorded; especially with reference thyroid function. The important investigations as prescribed by the physician were also recorded. patient’s serum level of T4, T3, FT4, FT3 and TSH were measured for 748 patients. The venous blood samples were taken from all the subjects in the morning after fasting overnight while TPOAb and TGAb level were measured abroad. 101 of patients with type1 diabetes mellitus were included in this study were investigated for celiac disease and Addison disease. Both diseases were diagnosed abroad. Celiac disease patients have been diagnosed by finding a positive anti-tissue transglutaminase (TTG) test and Addison disease diagnosed by finding positive 21-OH antibody. The present study was approved and done according to ethics guidelines of Tripoli Medical Center. Specimen collection and preparation for analysis Blood samples were collected into polyethylene test tubes. SST tubes were used for serum collection. From BD Vacutainer CO., Belliver Industrial Estate, Plymouth. Serum was separated by centrifuge for 5 min at 3,000 rpm to eliminate cell debris using Heraeus centrifuge from Germany. Serum samples were stored at -20°C until assay.T4; T3, FT4, FT3 and TSH were measurement by the

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