Colon Cancer Essay

Colon cancer is a condition in which polyps form in the lining of the colon (large intestine).

High-risk families include those whose members carry a mutation in the BRCA2 gene. The mutated BRCA2 gene is inherited in an autosomal dominant pattern. A child needs to inherit just one copy of the mutated gene to have an increased cancer risk. Children who have a parent with a BRCA2

Imagine having an almost 100% chance of developing colon cancer. That is what people are told with Familial Adenomatous Polyposis (FAP) if they do not have their over 100 polyps, or growths, removed. FAP is a genetic disorder where normal cells that line your large intestine can grow into cancerous tumors. These tumors must be removed before they become cancerous. This disorder is passed down from parents on the APC gene which is on your fifth chromosome. If the APC gene is mutated you are more likely to develop these growths which lead to cancer in your lifetime. This disorder has an autosomal dominant inheritance pattern, which means if either parent has just one dominant mutated APC gene you have a 50% chance of inheriting it. Symptoms of FAP do not just include the growths in your colon. They can also include skin changes, osteomas or bone growths, and extra or missing teeth.

Braca 2 is a mutation for breast and ovarian cancer, which means not only is there higher risk of getting breast cancer but ovarian cancer also at a much younger age and for men this gene presents its self in the form of breast cancer and prostate cancer.

There are twelve major types of cancer that affect most Americans and they can be related by the mutation of genes. Cancer is not just one disease, but a massive group with over 100 diseases by unrestrained and vicarious growth of the cells in the body and have the ability of the cells to propagate. One out of every four Americans will die from cancer. It is the second leading cause of death in this country, surpassed only by heart disease. Five to ten percent of cancer are genetic and hereditary. 1.2 million new cases are found in every year the United States, “Men have a one in two lifetime risk of developing cancer, and for women the risk is one in three” (Freivogel 201).

Imagine a cancer that creates cancer. Lynch syndrome, which is also known as hereditary nonpolyposis collectral cancer (HNCC) is an inherited disease that is a passed down trait that increases your chance of colon cancer and other cancers as well. The cause is the trait being passed through families. There are no symptoms since it is simply passed down. They just have increased probability of developing bowel, colon and other cancers.

Lynch syndrome is a cancer that can lead to colon cancer and other deadly cancers. The major causes of lynch syndrome is MLH1, MSH2, MSH6, PMS2, APC, BMPR1A, MUTYM, PTEN, SMAD4, STK11, TP55, EPCAM. People have a high risk of large bowel cancer as well as cancer of the endometrium, stomach, small bowel, upper urinary tract, ovaries, and the brain.

Cancer has been one of the biggest killers in the world for the past 100 years. Previously, before science advanced to the point that it’s at today; no one really understand where cancer came from or why it would suddenly generate inside a human’s body. But, since finding out the reasons behind all of the hundreds of different cancers, there’s almost always a cause/health defect.

Colorectal cancer is the third most common cancer among men and women in the United States, and mutations in the MUTYH gene significantly increase the risk of developing polyps that may evolve into cancer.1,2 Biallelic mutations in the MUTYH gene can lead to MYH-Associated Polyposis (MAP), which causes the growth of dozens to hundreds of polyps, furthering increasing the risk for colon cancer.2 Meanwhile, recent studies have shown that both biallelic and monoallelic mutations can contribute to bladder, ovarian, gastric, hepatobiliary, endometrial, and breast cancer.3 The MUTYH gene itself codes for the MYH glycosylase enzyme, which repairs mistakes in DNA caused by reactive oxygen species.3,4 Also a sign of oxidative stress, the oxidation product, 8-oxo-7,8-dihydro-2-deoxyguanosine (OG), mimics thymine, eventually matching with adenine and resulting in a complete loss of the cytosine-guanine pair.4 MUTYH removes the undamaged A base from the mismatched pair, aiding in the correction of such damage.4 However, when MUTYH is mutated, there is an increase in G to T mutations, which can eventually affect the tumor suppressor genes APC and K-ras and lead to tumor formation.4 The MUTYH variants Y165C and G382D are the most common mutations seen in individuals with MAP, and for this reason are of great interest in research working towards reducing the risk of colorectal cancer.2,4 In recent years, the CRISPR/Cas system for gene editing has become the preferred method for

Severe Familial Adenomatous Polyposis or Classical FAP is characterized by the formation of over 100 adenomas in the rectum and colon. (Ellis, 2008). Individuals with this form of the genetic disease will experience an earlier occurrence of tumors. According to Ellis (2008), adenomatous polyps are present in 15% of FAP individuals by the age of 10 years old, 50% by the age of 15 years old, and 75% by the age of 20 years old. Individuals who are aware of their APC gene mutation, should begin colonoscopy screenings as early as possible, preferably beginning at age 15. Since this disease is autosomal dominant, individuals who have a family history of FAP would need get tested for the APC mutation through blood samples, and then would proceed with colonoscopy screenings. Unfortunately, individuals with the severe or classical type of Familial Adenomatous Polyposis will almost 100% develop colorectal malignancy if left untreated by the age of 39. (Ellis, 2008). Ellis (2008) also presented that 7% of individuals would develop colorectal cancer by the age of 21. Individuals who experience severe FAP are at an increased risk of developing extra-colonic attributes such as, retinal hyperpigmentation, desmoid tumors, and even thyroid tumors. Retinal Hyperpigmentation or CHRPE (congenital hypertrophy of the retinal pigment epithelium) has be found to be associated

Colon cancer is caused by polyps or abnormal tissue that develop on the colon. By getting a colonscopy doctors can detect the polyp or tissue and remove it before it becomes a cancer. Physican Assistant Daniel Facchia says people 50 years old should get screened every ten years. "Colon cancer doesn't really have signs or symptoms

The paper can help us understand how transmissible cancers emerged and then we can link it to humans to avoid the evolution of cancer in humans.

Hssb1 is a protein which is critical for genome stability. It detects and promotes repair to damaged DNA and signals for other proteins to repair the cell, and if it is unsuccessful, it essentially tells the cell to commit suicide. Hssb1 ensures that the strands repairs properly however, if there is a mutation on the hssb1, the damage goes unrepaired. Cancer is a disease of bodily cells. Where cells normally divide and multiply in a controlled way through mitosis and controlled by cyclins, there can be mutations in these cells that cause control of the growth and multiplication of these cells to be lost. Cancer is a collection of these out-of-control cells which are known as malignant tumours. Mutations are random changes in the base sequence of the genes and in the cells can be caused by genes that can become

Colon cancer is considered as the second killer cancer in United States and Western Europe (1). Moreover, in the U.S it is the third common cancer ,and the risk is about 6 percent(1).It mostly affects elderly men and women, and the risk to the people who are African-Americans higher (1). Moreover, a personal history or family history makes the risk greater and the lifestyle effects too (1). For example, if the person overweight or suffers from obesity, that makes him under the risk. However, what is the Colon cancer?, and why is it a deadly disease ?.This will present in this essay based on a definition of colon cancer and its symptoms, screening, treatment.

This rapid cell growth is caused by a mutation in the DNA. The two most common genes that risk the chance of cancer are the p53 gene and the BRCA1 gene. The p53 gene is also known as “the guardian of the genome.” The function includes the ability to control cell cycles. This gene is mutated in more than half of cancers in humans. The Breast Cancer Gene, or BRCA1 is normally supposed to suppress tumor functions, but when this backfires, a tumor can begin to form.