Colorectal Cancer : An End Stage Disease

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The availability of the peritoneal disease in relation to colorectal cancer has a poor prognosis; therefore, traditional treatment such as systemic chemotherapy is usually associated with less survival rate. Currently, several innovative individuals globally are seeking to utilise more rapid and thorough strategies for the management of colorectal cancer. Cytoreductive surgery (CRS) is one of the most popularised methods of managing the disease in some selected patients. Peritoneal carcinomatosis has been established as one of the major causes of treatment failure among patients with colorectal cancer. Even though it is considered fatal, scientist have postulated that a localised peritoneal carcinomatosis without any other metastases can be considered as a regional disease metastasis and should be pliable to local-regional therapy.8 Despite the fact that curative liver resection for colorectal cancer is well established with a survival rate of 5 years, peritoneal cancer has been considered as an end stage disease. The notion that some individuals who have peritoneal carcinomatosis possess a regional disease rather than a metastatic malignancy has led to the development of multiple complex surgeries that can result in a macroscopic excision of the cancer completely (cytoreduction), which is combined with hyperthermic intraperitoneal chemotherapy to manage some of the microscopic diseases.15

Several scholars have advocated for the combination of surgical approaches since it
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