Colorectal Cancer : Cancer Of The Colon

Colorectal cancer is the third most commonly diagnosed cancer in the United States.4 According to the American Cancer Society, it starts with a growth of adenomatous polps on the inner lining of the colon or rectums and the growth happens over the course of several years to become cancer.5 Genetic factors that increase the risk for colorectal cancer are well established such as family history, ethnicity, and age. Pt is an African American female, and the incidence of colorectal cancer for African Americans remains higher than for other ethnic and racial groups.4 Another risk factor is increasing in age, especially in the sixth and seventh decades, and Pt is 71 years old. However, there is a major debate regarding if there is evidence that specific nutrients play a role in the risk of colorectal cancer. The American Institute for Cancer Research found that red meat, processed meat alcoholic drinks, body fatness, and abdominal fatness, and adult attained height were associated with an increased risk.4 It has also been found that calcium, dietary fiber, garlic, vitamin D, lycopene, and folic acid are associated with a decreased risk.4

Colon cancer is a condition in which polyps form in the lining of the colon (large intestine).

Colorectal cancer mainly starts at colon or the rectum. They are common in most of the way like features, but they have different treatment. What is the different between colon cancer and rectum cancer? Colon cancer happens first four to five feet of the large intestine and rectal cancer happens in the last few inches of the large intestine where it is connected to anus.

Sorry to say, some colon cancers might be present without any signs or symptoms. For this reason, it is very important to have regular colon screenings or (examinations) to detect these problems early. The best screening evaluation is a colonoscopy. On the other hand, most colon cancers are connected with signs or symptoms. One of the early signs of colon cancer is bleeding. Most of the time , tumors often bleed only small amounts, off and on, so that evidence of the blood is found only during chemical testing of the stool, which is called a fecal occult blood test. Other signs and symptoms include:

Colon cancer, also known as colorectal cancer is mostly found in adults age 50 and older. The most common symptoms are abdominal pain, weakness, fatigue, and weight loss. In the early stages of colon cancer not many symptoms are evident, when the symptoms do appear they vary depending on the location of where the growth is, and the size. Usually this type of cancer arrives in polyps, which are small non-cancerous growths that can become cancer over time.

The localized stage is stage where cancer is only found in the part of the body where it originated from (Surveillance, epidemiology, and end results program, n.d.). In Virginia, 39% of colorectal cancers are detected at the localized stage (Cancer in Virginia, 2014). The 2012 Behavioral Risk Factor Surveillance System (BRFSS) survey reported that 69% of Virginia adults age 50 or older reported that they have had a colon cancer screening (Cancer in Virginia, 2014).

The small intestine continues breaking down the food and absorbs most of the nutrients. The liver and the pancreas release bile and enzymes into the small bowel to aid in this process. The small intestine joins the large intestine or large bowel, a muscular tube about five feet long. The first part of the large bowel, called the colon continues to absorb water and mineral nutrients from the food matter and serves as a storage place for waste matter. The waste matter left after this process goes into the rectum, the final 6 inches, or so of the large bowel. From there, it passes out of the body through the anus.

Polyps are small, abnormal growths that occur on the lining of the colon. They vary in size from about a millimeter to several centimeters wide. While most polyps are not pre-cancerous or even have the potential to become cancerous, the connection between some types of polyps and colon cancer has been well-established.

You should know and be mindful of the signs of certain forms of cancer, such as colon cancer, should you hope to detect it early. Examples of colon cancer symptoms include sudden, inexplicable weight loss, bloody or thin stools and constant cramping. Get checked if you have these symptoms.

Colorectal cancer is the third most common cancer among men and women in the United States, and mutations in the MUTYH gene significantly increase the risk of developing polyps that may evolve into cancer.1,2 Biallelic mutations in the MUTYH gene can lead to MYH-Associated Polyposis (MAP), which causes the growth of dozens to hundreds of polyps, furthering increasing the risk for colon cancer.2 Meanwhile, recent studies have shown that both biallelic and monoallelic mutations can contribute to bladder, ovarian, gastric, hepatobiliary, endometrial, and breast cancer.3 The MUTYH gene itself codes for the MYH glycosylase enzyme, which repairs mistakes in DNA caused by reactive oxygen species.3,4 Also a sign of oxidative stress, the oxidation product, 8-oxo-7,8-dihydro-2-deoxyguanosine (OG), mimics thymine, eventually matching with adenine and resulting in a complete loss of the cytosine-guanine pair.4 MUTYH removes the undamaged A base from the mismatched pair, aiding in the correction of such damage.4 However, when MUTYH is mutated, there is an increase in G to T mutations, which can eventually affect the tumor suppressor genes APC and K-ras and lead to tumor formation.4 The MUTYH variants Y165C and G382D are the most common mutations seen in individuals with MAP, and for this reason are of great interest in research working towards reducing the risk of colorectal cancer.2,4 In recent years, the CRISPR/Cas system for gene editing has become the preferred method for

Colon cancer is caused by polyps or abnormal tissue that develop on the colon. By getting a colonscopy doctors can detect the polyp or tissue and remove it before it becomes a cancer. Physican Assistant Daniel Facchia says people 50 years old should get screened every ten years. "Colon cancer doesn't really have signs or symptoms

Colorectal cancer is brought about by an abnormal growth of cells that have the ability to invade or spread to other parts of the body in the colon or rectum of the large intestine.

Colon cancer is a malignant tumor coming after abnormal cell proliferation in the large intestine (colon) or in the rectum, the last part in the digestive system. All colon cancers start as benign tumor, which develops into cancer. There are some conditions that increase the risk of having colon cancer, such as being African American or of Eastern European descent; moreover, eating a lot of red meats can be a factor for Colorectal cancer. Colon cancer can be diagnosed by screening test before the tumor develops. If the patient has a risk of having cancer, there will be

Colon cancer is a cancer impacts the rectum or colon which is the large intestine , and sometimes doctors and scholars called it colorectal cancer (1). However, why is it a deadly disease?.As it known cancer takes 5 to 10 years to causes symptoms. Therefore, colon cancer sometimes does not give any symptoms because it starts as polyps in the colon for years , before it develops to cancer, so it cannot be noticeable(1). Moreover, Most people with colon cancer do not express any symptoms in early stages,

Colorectal cancer mainly starts at colon or the rectum. They are common in most of the way like features, but they have different treatment. What is the different between colon cancer and rectal cancer? Colon cancer happens first four to five feet of the large intestine and rectal cancer happens in the last few inches of the large intestine where it is connected to anus. (cancercenter.com)