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Colorectal Carcinoma Essay

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Colorectal carcinoma (CRC) is one of the lethal malignant diseases and is the third most common cancer and the fourth most common cause of cancer deaths worldwide. It is the third most common cancer in men (10% of all cancers in men worldwide) and second most in women (9.2% of all cancers in women worldwide)(1). It is a slow developing cancer that begins as a tumor or a tissue growth on the inner lining of the large bowel. The most common type of CRC is adenocarcinoma (more than 95%)(2). Even with advancements in the diagnostic technologies the detection is usually late however accurate pre-operative staging has a definite impact in the treatment plan and is important in selecting patients for pre-operative chemotherapy or radiotherapy or both.
GLOBOCAN 2012 says because of China’s large population size, approximately one-fifth of the world population, these Chinese data contribute significantly to the global burden of cancer: almost 22% of global new cancer cases and close to 27% of global cancer deaths occur in China(3). According to cancer
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Particularly, the diagnostic accuracy of pre-operative MRI in predicting the circumferential resection margin (CRM) of rectal cancer was well established through a prospective trial(8).The overall accuracy of MRI in predicting the pathologic stage of non-irradiated rectal cancer is 71-91% (mean 85%) for T staging, 43-85% (mean 75%) for N staging and 92-95% for CRM involvement(9). Due to the therapeutic effects of pre-operative CRT 30-50% of the patients experience down staging of rectal cancer(10). MRI is repeatedly performed after pre-operative CRT. However the interpretation of post CRT MRI in rectal cancer is not easy due to post radiation effects(9). In this study, we analyze on the prediction of pathologic stage with restaging MRI for rectal cancer patients who had received pre-operative
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