Compare And Contrast Aspirin And Acetaminophene

The goal of this experiment was to synthesize aspirin. In this experiment aspirin, also known as acetylsalicylic acid, was synthesized from salicylic acid and acetic anhydride. In the reaction the hydroxyl group on the benzene ring in salicylic acid reacted with acetic anhydride to form an ester functional group. This method of forming acetylsalicylic acid is an esterification reaction. Since this esterification reaction is not spontaneous, sulfuric acid was used as a catalyst to initiate the reaction. After the reaction was complete some unreacted acetic anhydride and salicylic acid was still be present in the solution as well as some sulfuric acid, aspirin, and acetic acid. Crystallization, which uses the principle of

The isolation of aspirin, acetaminophen, and caffeine from Excedrin utilized the differing acidities and polarities of the three compounds. Extraction involved separating the three components by reacting them with HCL and NaOH, while thin layer chromatography involved separating the isolated compounds on a TLC plate. The binder was the first component extracted; followed by aspirin, acetaminophen, and caffeine was extracted last since it is a neutral and polar compound. The entire process can be seen in figure 1. The most utilized methods of extraction were gravity filtration and vacuum filtration which are displayed in figures 3 and 4 respectively. These methods were utilized to separate compounds based upon their differing

Aspirin also known as acetylsalicylic acid is a salicylate drug, often used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an

It is used to treat chronic or acute pain. It works by inhibiting the chemical messengers called the prostaglandins. Prostaglandins help transmit pain signals, induce fever and promote inflammation of swelling of tissues, normally happens after an injury or illness. Acetaminophen helps by blocking the signals of pain to the body. Unlike NSAIDs it does not have an anti- inflammatory action. Acetaminophen is rapidly absorbed in the stomach and the small intestines. The therapeutic dose is 500mg every 4-6 hours. A single dose over one hundred and fifty mg/kg are considered toxic. Although most times it also depends on how often you take the medication and how often you accidently overdose. The statistic gives you some good idea of what we should be worried about. Acetaminophen toxicity can occur at any age. Most common in patients with chronic alcohol abuse or malnutrition. Children because of the incorrect weight and dosage given. Older teenager or adult patients will occur with intent to harm themselves. When it is ingested into the body, a normal dose is easily broken down through the liver enzymes and excreted through urine. However in large amounts it overwhelms the liver and it cannot be broken down as easy, thus killing the liver tissue. It is the most common cause of hepatic failure in adults, usually requiring a liver

Acetaminophen is a worldwide known drug used for aches and pains, but that is all that is thought of when the name is said. Because it is an over the counter medicine, nobody thinks about the effects it can have on you. In fact most people don't even read the warning label. In this paper, it will discuss all of the things nobody even bothers themself to look into. Such as common name/s, what it should be prescribed for, uses, side effects, warnings, drug interactions, and the chemical composition for it. This essay attempts to prove that Acetaminophen is more than just a benign remedy for discomfort.

Acetaminophen is a non-opioid analgesic. We are not sure about how acetaminophen reduces the pain. It could have an inhibitory effect on central prostaglandin synthesis (cyclooxygenase (COX)-2) as well as increase the pain threshold. Acetaminophen cure fever by inhibiting the formulation and release of prostaglandins in the CNS. It stops endogenous pyrogens at the hypothalamic thermoregulator center. Acetaminophen is effective on curing fever, and may also relieve mild pain caused by cancer. Compared with Ibuprofen, they have very similar effectiveness. Acetaminophen provides a faster and greater temperature drop than aspirin. Acetaminophen may cause vomiting, constipation, nausea, pruritus, and agitation. For more serious circumstances,

Acetaminophen is also found in combination with other active ingredients, otherwise known as combination medicines, which can treat conditions such as flu or cold symptoms, allergy, and sleeplessness. Medicines that contain this pain relieving drug can come in many physical forms including drops, syrups, and pills. It is easy for a person to not be able to recognize how much acetaminophen they are ingesting because of the many forms and medications it can be found in, therefore all people should be cautious and monitor their medicinal intake (U.S. Food and Drug Administration 2015).

The production of aspirin begins salicylic acid which has been derived from the active site of salicin found in willow bark. This is done through multi-step process where substrates of salicin are converted into more basic products such as salicylic acid. Salicylic acid cannot be consumed by itself due to the fact that it is bitter and irritates the stomach causing side effects such as nausea and internal bleeding within the stomach. This is due to the fact that salicylic acid exists in protonated form in the stomach; therefore, the pH of the salicylic acid is low, thus affecting the lining of the stomach. Therefore, to stabilise salicylic acid, it is synthesized into acetylsalicylic acid also known as aspirin. Acetylsalicylic acid is not pronated in the stomach and thus, the pH of acetylsalicylic acid is not as low compared to salicylic acid, thus it does not affect the lining of the stomach as much compared to salicylic acid.

Although the mechanism of action of acetaminophen is unclear, it is generally believed to work the same was as ibuprofen. Ibuprofen and acetaminophen produce therapeutic effects by reversibly inhibiting cyclooxygenase and thus blocking the synthesis of proinflammatory prostaglandins, prostacyclins and thromboxanes from arachidonic acid. The effects of these prostanoids include lowering the pain threshold thereby exaggerating pain perception. Inhibiting the synthesis of these prostanoids increases the pain

The periodic table has 118 elements. The compound we are going to focus on is acetaminophen. What is the drug acetaminophen? It is an over-the-counter drug that serves as a painkiller and a fever reducer. It is used to treat various conditions such as muscle aches, backache, toothaches, headaches, and arthritis. Although it is considered an analgesic because it is a pain reliever, it has no anti-inflammatory properties. Also, because it contains no anti-inflammatory properties, it is not a member of the non-steroidal anti-inflammatory drugs, also known as NSAIDs.

Acetaminophen also known as paracetamol and APAP, is a prescription and over-the-counter drug that is used to treat moderate pain and reduce fever. It is also paired with other ingredients. For example, acetaminophen is mixed with guaifenesin and phenylephrine to make the allergy medication Mucinex, acetaminophen is also used in over 600 other medications. When mixed with an opioid, such as, tramadol, it can be used to treat more severe pain. It is usually taken through the mouth but it can also be taken through injection and as a

Aspirin: A mainstay at pharmacies ever since its invention, aspirin is great for fevers, colds, and headaches. It even reduces the risk of heart attacks, but like ibuprofen, it's hard on the stomach.

of prostaglandin E2, which lessen the hypothalamic target point to reduce fever, and creating active the descending inhibitory serotonergic pathways to produce analgesia. Even though acetaminophen have similarities with the analgesic and antipyretic properties of other COX inhibitors like the aspirin and the non-steroidal anti-inflammatory drugs (NSAIDs), still it does not possess considerable anti-inflammatory properties. Contrary to aspirin, acetaminophens do not hinder thromboxane and, as such, aggregation of platelet does not change.

Aspirin is metastasized in the kidneys and acetaminophen in the liver, so maximum pain relief can be achieved

Paracetamol, also known as acetaminophen belongs to a class of drugs called analgesics (pain relievers) and antipyretics (fever reducers). The exact mechanism of action of acetaminophen is not known. Acetaminophen relieves pain by elevating the pain threshold, that is, by requiring a greater amount of pain to develop before it is felt by a person. It reduces fever through its action on the heat regulating centre of the brain. Specifically, it tells the centre to lower the body’s temperature when the temperature is elevated. Acetaminophen relieves pain in mild arthritis but has no effect on the underlying inflammation, redness, and swelling of the joint.