Controversy Over Administering Naloxone Hydrochloride

Part of this team are pharmacy interns who distribute naloxone (Narcan) rescue kits to the patient every saturday morning. The naloxone rescue kits were donated by the Steve Rummler Hope Foundation. The Steve Rummler Hope Foundation partnered with HCMC with a mission to heighten awareness of the dilemma of chronic pain and the disease of addiction and to improve the associated care process.4 The pharmacy intern spends about fifteen minutes educating the patients on signs and symptoms of opioid overdose, how to respond and how to use the naloxone rescue kits. This program has been successful with distribution of a total of 150 kits as of October of 2016. In addition, patients often provide success stories of occasions when they saved the lives of a loved one or a friend using the naloxone rescue

The topic of Narcan is a relatively new concept, since it has only been easily obtainable in the past few years. The major debate on Narcan use is will it become a bigger issue the it fixes. Governor Tom Wolf in April made it public that all state police cars will have doses of the life-saving drug; Narcan (Murrysville). Supports, of this drug look at the fact that is has been credited with saving around one thousand people across the state (Murrysville). Furthermore, that there have been more than two thousand overdoses deaths, in Allegheny County since 2008; and that Narcan would have given those people a better chance to live. Equally important, is the negative-side of Narcan. Tom Wolf in February, made it public knowledge that free doses of Narcan, will be given to schools that want it. Those who believe Narcan will become detrimental to the fight against this epidemic have good reason to. Such as, comments from Dr. Neil Capretto who is the medical director at Gateway Rehabilitation Center; has talked before about his teenaged patients, that would use heroin or other opioids in the middle of school (Pennsylvania). If Narcan, is so accessible like in schools, police cars, and can be bought for personal use, this could allow people to push the limits on using these drugs. Also, by allowing it to used whenever is going to be like adding gasoline to a flame, it will speed the

With the approval of this drug, in just Ohio, 2,200 lives were saved from Narcan (Ison). So It is obvious that Narcan has saved numerous lives, but with anything, there are cons to this wonder drug. The most obvious are the false sense of security that makes opioid abuse seem less life threatening, and may also encourage heroin use. However, the extreme cost of an overdose and diseases that comes with heroin abuse are only going to increase because of Narcan.

Heroin, a powerful narcotic, acts upon the brain as a painkiller, increasing physical addiction and ongoing emotional dependence (Schaffer Library of…). Heroin has many challenging and highly risky effects on the user, all the more hazardous if overdosing is present. This extremely dangerous drug, heroin, will never cease being used, but may cease the existence of an individual.

Last year there were over 64,000 reported opioid-related deaths in the United States – making it the leading cause of accidental death in people under the age of 50 in this country (Katz). Opioids, also referred to as painkillers, have become a growing problem over the past two decades particularly in rural communities all across the country where the death rates are higher per capita compared to the death rate in cities (“America’s Opioid Epidemic is Worsening”). These narcotics, such as codeine, fentanyl, hydrocodone, morphine and oxycodone are extremely addictive and, as a result, this silent killer has quadrupled the overdose death toll since 1999

Naloxone is an opioid antagonist that is designed to rapidly reverse opioid overdose. Take home naloxone programs aim to reduce overdose fatalities by training community members as first responders to opioid overdoses. Opioid users are provided with naloxone

Opioids are a class of drugs used to help an individual’s pain perception. They include prescriptive and nonprescriptive medications: morphine, oxycodone, hydrocodone, codeine, and fentanyl. Heroin is also an opioid, but it is a classified Schedule 1 illegal drug.

However, this step isn't necessarily to cure the epidemic, but rather to keep it from becoming more catastrophic. This drug is not to be used as away of getting people to stop using opioids in anyway, but rather just keep them from dieing when they do use opioids. Then those who have overdosed can go get help from the types of programs previously mentioned. This is the most important step because it needs to be put into action immediately. If this step takes as long as predicted then the epidemic will only be getting worse and far too many lives will be taken away yet again by opioids. Although, “While DuPage County is the only county currently using intranasal naloxone, Kane, Lake, McHenry and Will Counties are set to implement plans to use both forms of naloxone in the coming months” (Kirk launches suburban anti-heroin task force 1 death every 3 days on average since 2012; using narcan during an overdose was 100% effective in Dupage County, States News

Once more, the lives of Canadians are being claimed by addiction and overdose of a new drug in the streets. For those of you who don’t know what fentanyl is, it’s a powerful opioid, 100 times stronger than morphine, that is often prescribed to help patients manage moderate to severe pain. As a highly addictive substance, many are now dependent on it, and it is one of the most frequent causes of drug overdose. Readily available for purchase online are quantities of pure fentanyl from China, but when improperly diluted in clandestine labs, it can lead to an immediate overdose. Recently, an antidote for opioid overdose called naloxone has become available without prescription, so that anyone can use it. Fentanyl has become a severe problem in the past few years, and while we yet to find a way to eliminate dependence on this drug, we must keep those who use it safe.

Nevertheless, several studies have shown that intranasal Naloxone absorbs in the same amount of time as intravenous Naloxone when the administrator accounts for the time Naloxone takes for an I.V. to be placed. Granted the absorption rate is slower for intranasal admission versus intravenous, the nasal route still has a valuable blood supply allowing Naloxone to be absorbed efficiently (Robison and Wermeling 2131). Intranasal administration is effective enough to reverse drug overdose. Intranasal administration can be repeated every three minutes and last for 180 minutes while intravenous Naloxone

The reason that this drug can be so intense and dangerous is because it falls into the category II narcotics. Many commonly known narcotics include opium, morphine, and heroin. The addiction rate of any of these drugs is phenomenal. Narcotics are central nervous system depressants that relieve pain without causing the loss of consciousness. They can also produce feelings drowsiness, mental confusion and euphoria. The analgesic effects of narcotics result from the drugs’ effects on the emotional aspects of pain. Many patients that experience intense pain say that after the administration of the narcotic, their pain is as intense as ever but no longer as bothersome. Because narcotics block the emotional side effects of pain they make it much more bearable.

One effort York County is making is equipping officers with the lifesaving drug NARCAN. NARCAN is a drug that can reverse the effects of an overdose of heroin or any opioid,

Today, Naloxone is now being prescribed and dispensed to people at risk of opioid overdose. The number of overdose deaths has quadrupled since 1999. Statistics show that increased availability, relatively low price (compared to prescription opioids), and high purity of heroin in the United States is one of the reasons why death rates are so high. From 2000 to 2015, more than half a million people died from drug overdoses. Every day, approximately 91 Americans die from an opioid overdose. It is a proven fact that most people who are addicted suffer the most overdoses. Anyone taking drugs can suffer an opiate overdose, especially when they take more than prescribed or if they combine opiates with other CNS (Central Nervous System) depressants with alcohol. It's rare for someone to die immediately from an overdose, it's usually a very slow process that takes anywhere from a few minutes to a few hours. After you administer the Naloxone, it lasts between 30-90 minutes before the overdose begins to recur. Also, Naloxone can also cause an uncomfortable withdrawal feeling; This is because it blocks the action of opioids in the

If a person has taken opioids and is then given Narcan, the opioids will be knocked out of the opiate receptors in the brain. Narcan can help even if opioids are taken with alcohol or other drugs. According to The Opiate Antidote to Save a Life, “After a dose of Narcan the person should begin to breathe more normally and it will become easier to wake them. Brain damage can occur within only a few minutes of an opioid overdose as the result of a lack of oxygen to the brain.”

1Fentanyl is a powerful synthetic opiate analgesic, which has a primary function in managing malignant and non-malignant contractible pain, similar to morphine however it is more potent. This is because fentanyl has an octanol-water partition of 9550 compared to morphine, which has 6. This effectively demonstrates that fentanyl is highly lipid soluble, crossing the blood brain barrier more rapidly. Hence it has a quicker reaction time but at a shorter duration compared to morphine. It is commonly used to treat patients with severe pain or patients experiencing pain after a surgery. Fentanyl can also be used to treat patients with chronic pain that are physically tolerant to opiates. Patients who are not physically tolerant to opiates