Coronary Antiquilibrium Score

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Resistance in the heart could lead to problems in blood pumping to the entire body. In order to identify how much coronary plaque is present in the walls of the artery, Computed Tomographic (CT) scans are used to help find the calcium score. The calcium score can be arranged from 0 to 100, and is measured through the Agatston score.1, 4 There have been many researches and follow ups of patients who were at risk for CHD or atherosclerosis and were labeled with a calcium score. It was found that Individuals with a CAC score of 100 or more had an incidence density of 22.4 deaths per 100 people observed for 12.5 years.4 Any CAC in early adult life (younger than 50), even in those with very low scores, indicates significant risk of having and possibly…show more content…
Cholesterol is a lipid that helps manufacture vitamin D on the surface of the skin, produces hormones, maintains cell membranes, and possibly helps cell connections in the brain.3 Based on what is known about calcium transporting throughout the body we can infer that cholesterol also has a similar process. When there is an imbalance of cholesterol homeostasis we can have high density lipoprotein (HDL) which is known as good cholesterol, or low-density lipoproteins (LDL) which is known as bad cholesterol. Lipoproteins differ in size, shape, composition, function, and contribute to vascular…show more content…
Calcium needs to be released first and needs to be obtained in the body in order for the body to carry out its function. Calcium or calcium ion (Ca2+) is stored in the sacroplasmic reticulum (SR) to start contraction for the muscles.11 In the case of the cardiac muscle, it would start contraction through the Sodium-Calcium exchange (NCX) and with limited help of the SR. Sodium ions (Na+) would enter from the dyadic cleft, the space where the cell membrane and SR are in close proximity.11 This would cause Ca2+ to flow out of the cell. In order for Ca2+ to reenter it has to go through Ca2+ channels and so Ca2+ would be released.11 Excitation-contraction coupling relies on the dyadic cleft of Ca2+ to be released. Understanding how NCX works could help provide treatment for HF because the cardiac muscle could be manipulated to contract. It may be possible to remove the NCX because it can cause too much Ca2+ to be stored in the SR and cause arrhythmias and cell death.11 This would lead to a pathway to fixing any heart failure
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