Coronary Artery Disease Research Paper

According to the CDC, cardiovascular disease claims 614,348 lives in 2014 making it the leading cause of death in the United States, accounting for 46.9% of all deaths in 2014. This percentage is estimated to increase threefold by the end of 2016 (Heron, 2016). This is a significant issue, mainly because, for the most part this is a preventable ailment. If not closely control, this can quickly become an epidemic as the overall death rate increase each year. To fully understand this disease, we need to first look at the root cause, coronary artery disease.

1). Chest X-ray was normal. Initial laboratory studies were remarkable for white blood cells count of 12.1K, a creatine kinase MB fraction of < 3 mm was associated with significant reductions in restenosis and the rate of target vessel revascularization19. In SES-SMART trial patients were randomly assigned to receive a Sirolimus-eluting or bare-metal stent in small coronary artery. Sirolimus stent was associated with significant reductions in the rates of angiographic restenosis (primary outcome), target lesion revascularization and MI at 8 months20. The composite clinical endpoint ( death, non-fatal MI, ischemia- driven target lesion revascularization, and cerebrovascular accidents) was significantly lower with the sirolimus-eluting stent21. In the TAXUS V trial, in the subset of patients with small coronary arteries, the paclitaxel stent was associated with significant reductions in angiographic restenosis and target lesion revascularization at nine months compared to bare metal stents22. Although DES improves target lesion revascularization rates compared to bare-metal stents in small vessels, the absolute rates are still higher in small vessels than large

Coronary Heart Disease (CHD) it is also know as Coronary Artery Disease. It happens when the blood vessels delivering to the heart develop blockage or are narrowed by plaque, which reduces the flow of the blood, oxygen and nutrients supplied to the heart. If this happens the person starts to feel chest pain (also known as angina pectoris) and then it lead to the person to have a heart attack. It is known to be the main factor to cause cardiac arrest and it can be fatal unless the heart is restarted in minutes.

Artery coronariasLa artery disease coronary (EAC) affects more than 15 million Americans, being both the most common type of cardiovascular disease. The EAC and its complications, such as arrhythmia, angina pectoris and heart attack, are the main causes of death in the United States. The most frequent cause of EAC is a disease known as 'atherosclerosis' that occurs when forms a waxy substance within the arteries that irrigate the heart. This substance, called «plate», is composed of cholesterol, fatty, calcium and a coagulant substance called «fibrin». Identified two types of plate: plate hard and soft plate.

Some lifestyle-related conditions and decisions increase the likelihood of a person having heart disease. Some examples are diabetes, overweight and obesity, poor diet, lack of physical activity and excessive consumption of alcohol. High blood pressure, low-density lipoprotein (BAD) cholesterol, and smoking are key risk factors for heart disease. LBD is considered to be "bad" cholesterol because having high levels can lead to accumulation in the arteries, which can cause heart disease and stroke. If you lower your blood pressure and cholesterol, and if you do not smoke, you will reduce your chances of having heart disease. Now, in case of emergency, angioplasty which is the best treatment needs to get done. In this case we need to kake in consideration that not all hospitals are capable to made the process, so we need to be aware of our options. After the angioplasty you should take a daily medication, which will help your heart adapt to the implanted stents and they will not close again, a phenomenon known as restenosis, his medication should not be forgotten any day in order to minimize future

Coronary artery disease (CAD), also known as coronary heart disease, is the leading cause of mortality in both men and women in the United States today. It has been reported by the Centers for Disease Control and Prevention that CAD accounted for nearly 616,000 deaths in 2011 and was responsible for 1 in 4 deaths in the U.S. in the same year. 1 Coronary artery disease is a progressive disease where the major arterial vessels supplying the heart become occluded and sclerotic due to the buildup of plaque in the inner walls of the artery through a process called atherosclerosis. 2 CAD eventually leads to heart failure and a myocardial infarction (MI).

The stent is inserted into the artery by balloon angioplasty, to expand the vessel walls in order to return blood flow back to normal. There are two types of stents, bare-metal stents and drug-eluting stents. Once a BMS is inserted into the vessel, it become fully endothelialized.. However, The animation explains that in about 1/3 of BMS implants, restenosis occurs. On the other hand DES were developed to combat this issue. The polymer coating on the DES contains a drug which aids in the inhibition of restenosis. However, the endothelialization process for drug-eluting stents has shown to be problematic, which can in time cause stent thrombosis, which can possibly lead to myocardial infarction. It is important to note that these stents should be used in patients how do not have complex coronary stenosis because the off-label use is not completely understood and has a higher risk of

The coronary arteries supply oxygenated blood to the heart muscle. Plaque is a substance that can clog these arteries and cause a condition called atherosclerosis. The buildup of plaque can occur over many years which can ultimately lead to coronary heart disease (CHD). Plaque can harden and cause the arteries to become narrowed. This reduces the flow of oxygenated blood. Plaque may also burst and a blood clot may form causing a blockage of blood flow to the heart. In result to the blockage angina or a myocardium infarction can occur.

With the increased consumption of fast-food and poor lifestyle choices, we have become an increasingly obese nation. For this reason, diseases such as cardiovascular disease have been on the rise. Cardiovascular disease is the combined term for a number of diseases concerning the heart and the blood vessels. Many of these life threatening diseases are related to a condition called atherosclerosis. The condition creates plaque build-up on the walls of the blood vessels. The plaque effects the flow of blood making it harder and can lead to blood clots which stops the flow of blood altogether. The two main effects to this are heart attacks and strokes however, other types of cardiovascular disease includes complete heart failure, arrhythmia

Coronary artery disease is the most common type of heart disease and the #1 cause of death for both men and women in the United States resulting in about 375,000 deaths a year. (National Heart, Lung, and Blood Institute, 2014). This disease refers to “any vascular disorder that arrows or occludes the coronary arteries leading to myocardial ischemia” (Huether & McCane, 2012). It occurs when the arteries that supply blood and oxygen to the heart becomes hardened and narrowed. Also, factors such as smoking, high levels of fat & cholesterol in the blood, hypertension, high levels of sugar in the blood, and blood vessel inflammation damage the inner layers of the coronary arteries. “This disease is prevalent in younger and elderly individuals. Coronary artery calcium is highly predicative of coronary heart disease event risk across all age groups” (Tota-Maharaj et al, 2014). Coronary artery disease is caused by the buildup of cholesterol and fatty deposits, or plaque, in the inner walls of the coronary arteries in a process called atherosclerosis. Normally, the coronary arteries are smooth and elastic, lined with a layer of cells called the endothelium. The endothelium acts as a physical barrier between the blood stream and the coronary artery walls.

Mr. Harry Bright has undergone a procedure called percutaneous transluminal coronary intervention (PTCI) via femoral approach for the treatment of his progressive unstable angina. Femoral artery is the most common access site used for PCI because of its size and its direct passageway to the heart (Young, 2014 p.431; Cosman, Arthur, Bryant-Lukosius, Strachan, 2015 p.180). In this procedure, a cardiac catheter followed by a stent is inserted to the artery to dilate the occluded blood vessel and improve blood flow (Young, 2014 p.430). The occlusive atherosclerotic plaque are usually associated with Mr. Bright’s diabetes, hypetension and smoking history. Contrary to the positive effect of PTCI, bleeding and hematoma formation are the most typical

There are many new technologies and advancements within the cardiovascular community. These technologies and advancements happen frequently and are to help better the equipment for better outcomes for patients treated. One of the new technologies that has made great strides is the orbital atherectomy. Orbital atherectomy is a technology created by a company called Cardiovascular Systems Inc. (CSI). What the new device does is make it easier and safer for balloon and stent administration within a heavily calcified vessel. The ORBIT is a new instrument used during a catheterization procedure that can break up calcified plaque. Patients that have a clogged coronary artery, that is restricting the blood flow to the heart would benefit from the

The evolution of percutaneous coronary intervention (PCI) from plain old balloon angioplasty (POBA) in 1977, to bare metal stents (BMS) in 1986, through the revolutionary introduction of drug-eluting stents (DES) in 2003 which successfully treated the “Achilles heal” of BMS (neointimal proliferation and restenosis) has provided significant iterative improvement in platform design and performance. Adverse clinical events to 1-year following stent

The stent will be placed where it can be expanded to hold the artery open. Some stents are designed to simply keep the artery held open. Other stents used are drug-eluting stents. These stents are coated with pharmacologic agents that work to prevent restenosis of the artery.

The researchers performed a randomized study of patients with drug-eluting stents that underwent 6 or 24 month DAPT treatment. The researchers began by performing an aspirin-resistant test and separated those that responded well to aspirin. The researchers collected data from 6- 12-24- and 36- month follow ups with the patients’ doctors.