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Coronary Artery Diseases

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INTRODUCTION

Coronary artery diseases (CAD) as a kind of cardiovascular diseases are considered to be the major causes of morbidity and mortality in type 2 diabetic patients (Buse JB et al, 2007) (Stolar MW & Chilton RJ, 2003).

Diabetic patients frequently present various risk factors for CAD, including hyperglycemia,fluctuation of blood glucose levels, obesity, hyperlipidemia and hypertension etc (Stolar MW & Chilton RJ, 2003).

Glycaemic disorders in particular are the most important component of these risk factors.

Some studies concluded that patients with chronic hyperglycemia, which can be estamited by the determination of hemoglobin A1c (HbA1c) level integrating both basal and postprandial hyperglycemia (Sacks DB et al, 2002)(Gorus …show more content…

Recent studies have found that glycemic variability may play a substantial role in the pathogenesis of atherosclerosis suggesting that it may be an independent risk factor for developing cardiovascular diseases in diabetic patients (Ceriello A et al, 2008)(Monnier L et al, 2006)(Hu Y et al, 2010)(Temelkova-Kurktschiev TS et al, 2000). However, in the avaliable literature studies that specifically evaluate the role of glycemic variability in increasing severity of CAD are still scarce.

Therefore, the aim of this study is to evaluate the association between glycemic variability and severity of coronary artery disease (CAD) in patients with type 2 diabetes mellitus (T2DM).
Rationale

To understand the reason behined one of the major causes of morbidity and mortality in diabetic patients that is coronary artery diseases. To determine the effect of Glycemic Variability (GV) on morbidity and mortality in a population of diabetic …show more content…

As the effect of GV on the diabetic patients is a chronic ongoing effect, which has to be studied during the lifetime of these patients. Also changes occur in the patient's coronary arteries can only be evaluated by doing investigational tool (angiography).

Research Question Is there a relationship between glycaemic variability and severity of coronary artery diseases?

Aim of the work
The aim of the study is to evaluate association between glycemic variability and severity of coronary artery disease(CAD) in patients with type2 diabetes mellitus(T2DM). Objective
1)To assess glycaemic variability (FBS,RBS and HBA1C) in adults with type2 DM.
2)To assess interday variability of serum glucose,by calculatingthe SD of the fasting blood glucose concentration ,mean of daily differences(MODD) using hourly blood samples taken over 24 hours,and it is correlation with severity of coronary artery disease as indicating by angiographic finding ,using Gensini score in diabetic patients,the angiography will be performing on the same day of taking blood sugar

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