Corynebacterium glutamicum was first isolated from a soil sample contaminated by bird feces in 1956 as an L-glutamate producer [Kinoshita, et al., 1957] [Eggeling & Sahm, 2001]. This bacterium encompasses beneficial traits as a cell factory, such as non-endospore forming, non-endotoxin containing, and minimum extracellular protein producing [Wachi, 2013]. Improvement in genome and fermentation technologies allow utilization of this bacteria to synthesize amino acids in industrial scale. Accordingly, C. glutamicum is considered as one of the most accommodating bacterial species for white biotechnology.
Corynebacterium belongs to the mycolic acid containing actinomycetes, also known as CMN (Corynebacterium, Mycobacterium, Nocardia) group. Mycolic