Critical Appraisal Of The Clinical Pharmacist

1370 Words Jan 18th, 2016 6 Pages
Critical appraisal of the role of the clinical pharmacist in Cystic Fibrosis

Wael Yahya A Khawagi Student ID: 14122011

Critical appraisal of the role of the clinical pharmacist in Cystic Fibrosis

Cystic fibrosis (CF) is a life-shortening, genetic, multisystem disease. It mainly affects the respiratory and the gastrointestinal systems, but it also can involve the endocrine system, sweat glands, reproductive system, haematological system, bones and joints (Chisholm-Burns et al., 2013). The pathophysiology of CF is caused by a mutation in the CFTR (cystic fibrosis transmembrane conductance regulator) gene, which acts as a chloride channel on epithelial cells, and it has many other regulatory roles, for instance it works on inhibiting sodium transport through the epithelial sodium channel. In order for the disease to develop it require two copies of the abnormal gene i.e. an autosomal recessive disease (Davies, Alton and Bush, 2007). Until now, almost 2,000 different CFTR mutations have been discovered and grouped into 5 classes. The most common mutation, appearing in more than 80% of the patients, is in class II, which is called delta-F508 (ΔF508). (De Boeck, Zolin, Cuppens, Olesen & Viviani, 2014). The clinical manifestations of the disease can vary between patients, according to the age, the severity of the disease and the involved body system. It can appear from an early age and continues throughout the life of the patient (O 'Sullivan and Freedman,…

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