Crohn's Disease: A Literature Review

Crohn’s disease (CD) is a systemic auto-immune disease that is marked by abnormal inflammation of the gastrointestinal (GI) tract, it affects any part of the GI tract from mouth to anus. CD mainly presents in three areas: the small intestine, the colon, and the perianal region. CD mostly occurs between the ages of 15 and 30 years, or between the ages of 60 and 80 years of age. The exact etiology of Crohn’s disease is unknown. As stated by Mazal (2014) “Genetic predisposition—especially familial aggregation—seems to be the strongest independent indicator of which individuals will develop Crohn disease” (p.298). An increase diet in milk protein, milk protein and polysturated fatty acids is also a possible factor in disease incidences. Smoking may also double the risk of developing CD.

C. Thesis Statement: With autoimmune diseases such as Multiple Sclerosis on a steady rise over the past decade, three major factors must be considered: the possible causes, common symptoms, and

Crohn’s disease is a chronic inflammatory bowel disease that causes an inflammation of the GI tract. The symptoms of this disease are mild to severe, and they commonly include varying degrees of abdominal pain, frequent diarrhea, fatigue, rectal bleeding, and unexplained weight loss. Crohn’s disease is a lifelong and progressive condition that leaves approximately seven-hundred thousand Americans without a cure. As disheartening as it is, it has proven my little sister to be the fighter of my family and has lead me to admire her for it. Her battle with her new health condition has shown me how to brave and optimistic in the most trying of situations.

“The colon cancer vs. Crohn’s disease debate is generating a lot of interest in the medical community. Every year in the U.S., approximately 57,000 people die from colorectal cancer and 147,000 new cases are diagnosed”states Dr. Victor Marchione. Crohn's disease is a new disease that was introduced into today's society in 2015. 1.4 million Americans have Crohn’s disease or ulcerative colitis. Of those, about 700,000 have Crohn’s has been diagnosed in the years between 1992 and 2004 just from a doctor's visit. People have came up with different ways that we can help and prevent the disease such as Surgery, Conferences and “ KEY TO PROCESS “.

Website dedicated to Crohn’s and Colitis. This specific page within the website talks about diet with inflammatory digestive diseases. However, contradictory to many of the other articles and websites, this one states that diet does not in fact play as a major contributor in contracting an inflammatory disease. However, they do state that diet can help manage symptoms after diagnosis. This article is to help guide patients to understand Crohn’s and how to best control

Crohn’s disease was first discovered in 1932 by three doctors named Burrill Crohn, Leon Ginzberg, and Gordon D. Oppenheimer. The Crohn’s & Colitis Foundation of America (2014) declared “these doctors collected data from 14 patients with symptoms of abdominal cramps, diarrhea, fever, and weight loss, which showed that the symptoms were not the result of tuberculosis or any other known disease. They described a new disease entity, which was first called regional ileitis, and later, Crohn’s disease” (p. 7). Even though Crohn’s Disease was discovered over 80 years ago, there is no cure, but there is constantly more new information being found out about this disease.

This review will explain Crohn’s disease and Ulcerative colitis, two types of inflammatory bowel disease that affect millions of people. These diseases are chronic that affects certain parts of the intestine gastrointestinal tract. People who has this disease are troubled with a variety of side effects that they will have to live with for the rest of their lives. To this day, there are no medical cure for these diseases, however there are several treatment options that are helpful. These diseases are still being studied for researchers to fully understand the causes, possible preventions, and cure for IBDs. Countless researches and studies are still under development, there have been many discoveries thus far, but nothing concrete.

This prevents the release of the inflammatory factors which cause Crohn’s disease; however it also prevents the intended effects of the cell, such as inducing cell apoptosis, and inhibiting viral replication. Due to these side effects, anti-TNF-α treatment can result in an increased risk of cancer, infection and fungal infections. Furthermore, although effective in most patients, 30% of people who receive this treatment do not respond and continue to show symptoms from Crohn’s [6]. This suggests that TNF-α is not the only cause of the disease, adding to the complexity of the

Crohn’s Disease is a chronic inflammation of the gastrointestinal (“GI”) tract that can occur anywhere along the alimentary canal from the mouth to the anus. It is the second most common form of Inflammatory Bowel Disease (“IBD”) after Ulcerative Colitis and can be hard to distinguish from it due to the overlapping signs and symptoms. They are not, however, the same. With Crohn’s Disease the inflammation most often occurs in the small intestine at the end of the ileum and continues into the beginning of the colon, but inflammation may be found in multiple places along the digestive tract at the same time with normal, unaffected areas in between the distended areas. Furthermore, the disease will spread through every

Crohn’s disease (CD) involves the entire alimentary tract and is characterized by focal exacerbations, with intermittent activity throughout the patient’s life. The etiology of Crohn’s disease (CD) remains largely unexplained, but there have been major advances in recent years concerning the pathogenic mechanisms underlying intestinal inflammation. There is a multifactorial character of the disease, in which a genetic predisposition, the external environment, intestinal microbial flora, and the immune system are all involved. Systemic symptoms include unexplained fever, weight loss, and extraintestinal symptoms such as arthralgias and perianal abscess. Delays by the patient in seeking medical help and by the physician to identify the disease

The fundamental purpose of this paper is to apprise to the reader pivotal information on the inflammatory bowel disorder known as Crohn’s Disease (CD). It is a rare disease that is usually not wanted to be discussed by its sufferers, due to its sensitive nature of being a digestive problem. Luckily, as this paper will show, it is now an issue slowly, but surely, being explored more openly. A short introduction to the chronic disease will be divulged, pathophysiology and etiology will be discussed to prepare the reader. Works researched will include articles by Brent A. Lashner (2013) and Lindsey Konkel (2015). Symptoms, susceptibility, and diagnosis found on numerous resourceful web sites will be provided. Other information will include risk factors and examples of typical tests given to diagnose Crohn’s Disease in possible sufferers. All articles and web sites used corroborate with each other, information is consistent and validated. This paper will also delve into possible management strategies for those affected by CD.

How would you feel if one day a doctor said you can not have your favorite food in the world or else it will be bad? As soon as my boyfriend of four years realized he had Crohn's Disease, that became his reality. What would be a normal date going out to his favorite restaurant and getting his favorite food turned to a stomach ache filled nightmare. It all started in the beginning of 2015 when he was having constant stomach pains that only cleared up if he didn’t eat. As his stomach aches grew worse and his health was declining he decided to go to the doctor to have numerous tests done which made it clear to the doctors that he did in fact had a minor case of Crohn’s Disease and would have to have major dietary restrictions. I could see part

Inflammatory Diseases, in today's society pretty much everyone has heard of at least one of them. Lupus, rheumatoid arthritis, multiple sclerosis, psoriatic arthritis, Crohn's disease, the list of disorders goes on and on, and their effects can range from mild to life-altering. They all have one thing in common however, individuals with these diseases have overactive immune systems which then begin to attack the body's healthy cells. As the numbers of individuals with inflammatory diseases continues to rise the question then becomes, how did these disorders of the immune system begin in the first place? This article seeks to provide some answers to this question by detailing the work

This article, which was submitted for review in 2013, was written by Lennard YW Lee, Ramez Golmohamad, and George MacFaul of the Department of Gastroenterology, Milton Keynes NHS Foundation Trust, Standing Way, Milton Keynes MK65LD, United Kingdom. The paper was accepted for publication August 25, 2013.

I was right, I did change because of Crohn’s Disease and my life will never be how it was before, but with time I came to realize that this was for the best. Crohn’s Disease was one of the biggest eye openers in my life. This illness allowed me to develop a deeper understanding of life and gain the strength to mature mentally, emotionally and intellectually. Being chronically ill taught me that if I can overcome the physical and emotional challenges of Crohn’s Disease, then I could overcome anything. I quickly transformed any paralyzing fears and insecurities about having being ill into a determined drive for success. I maintained a 3.91 GPA whilst I was either working or interning, even through times of flare-ups.